3 ms·
Right. And RCTs not showing things than can be seen in larger observational studies seems plausibly related to the problems with RCTs, for instance statistical
by warshinder 3mo ago
Right. And RCTs not showing things than can be seen in larger observational studies seems plausibly related to the problems with RCTs, for instance statistical power being generally lower because n sizes are lower, attrition is an issue, etc… I want to believe the research though, especially since I like most smart people are going to get the Shingrix shot anyway.
- reenorap 3mo agoIt’s the opposite. Observational studies are very biased by the selection process and the only way to get signal from them is rct.
- warshinder 3mo agoSo you have a 30 person RCT, half the treatment bails midway through, you include the assigned but not treated (ITT) in the analysis. That’s going to give you the power to make a definitive statement while a large scale longitudinal with n=50,000 will not?
- reenorap 3mo ago[dead]