Also, despite GP's dismissal of the "low-hanging fruit" hypothesis, it is obviously true that we've found the easy-to-discover drugs, and therefore drugs would

Also, despite GP's dismissal of the "low-hanging fruit" hypothesis, it is obviously true that we've found the easy-to-discover drugs, and therefore drugs would get harder and harder to find. A flippant dismissal in an HN comment does not actually negate reality.