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I'm not a biologist so I can't say for sure, but it seems like it would be a lot easier to edit an existing living organism to produce those products than it wo

by TSiege 3mo ago

I'm not a biologist so I can't say for sure, but it seems like it would be a lot easier to edit an existing living organism to produce those products than it would be to create completely from scratch. We already do this with the process known as precision fermentation. We've gotten very good at editing genomes via CRISPR and related techniques and are only getting better https://en.wikipedia.org/wiki/Precision_fermentation https://en.wikipedia.org/wiki/Precision_fermentation

colordrops 3mo ago
It seems that eventually you could build much more flexible and powerful if you build from scratch. Hacking existing cells is a shortcut but longer term we may get grey goo.
- NetMageSCW 3mo ago
  I don’t think biological cells are likely to lead to grey goo the way nanobots are - we may just end up with green and pink goo instead of animals and plants though.
PaulHoule 3mo ago
It's desirable to have some kind of simple base to start from that is an easy-to-configure platform to deploy any kind of metabolic machinery. Their "minimal" cell is not quite a minimum product because it depends on prebuilt ribosomes and can't reproduce on it's own. No danger of gray goo! This is more like it https://www.jcvi.org/research/first-minimal-synthetic-bacterial-cell https://www.jcvi.org/research/first-minimal-synthetic-bacter... but those guys could probably add components to their cell to make it truly self-supporting although in biology there is a big difference between "barely works" and "high performance"
senkora 3mo ago
It seems like this cell barely evolves, because the system they built for duplicating the DNA makes very few errors. Natural life tends to evolve, which may have consequences for production. For example, quorn production has to be restarted from a seed population after ~1000 hours because it tends to evolve colonial variants that break the product standards: https://www.davidmoore.org.uk/21st_century_guidebook_to_fungi_platinum/Ch17_18.htm https://www.davidmoore.org.uk/21st_century_guidebook_to_fung...
- TSiege 3mo ago
  Very interesting! Thanks for sharing

by TSiege 3mo ago

colordrops 3mo ago

It seems that eventually you could build much more flexible and powerful if you build from scratch. Hacking existing cells is a shortcut but longer term we may get grey goo.

NetMageSCW 3mo ago
I don’t think biological cells are likely to lead to grey goo the way nanobots are - we may just end up with green and pink goo instead of animals and plants though.

PaulHoule 3mo ago

It's desirable to have some kind of simple base to start from that is an easy-to-configure platform to deploy any kind of metabolic machinery. Their "minimal" cell is not quite a minimum product because it depends on prebuilt ribosomes and can't reproduce on it's own. No danger of gray goo! This is more like it https://www.jcvi.org/research/first-minimal-synthetic-bacterial-cell https://www.jcvi.org/research/first-minimal-synthetic-bacter... but those guys could probably add components to their cell to make it truly self-supporting although in biology there is a big difference between "barely works" and "high performance"

senkora 3mo ago

It seems like this cell barely evolves, because the system they built for duplicating the DNA makes very few errors. Natural life tends to evolve, which may have consequences for production. For example, quorn production has to be restarted from a seed population after ~1000 hours because it tends to evolve colonial variants that break the product standards: https://www.davidmoore.org.uk/21st_century_guidebook_to_fungi_platinum/Ch17_18.htm https://www.davidmoore.org.uk/21st_century_guidebook_to_fung...

TSiege 3mo ago
Very interesting! Thanks for sharing