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Can you point me to anything about mitochondrial transplants? I'd love to see bat mitochondria transplanted into other mammals. They must have really superior o
by scotty79 4mo ago
Can you point me to anything about mitochondrial transplants? I'd love to see bat mitochondria transplanted into other mammals. They must have really superior ones given the energy expenditures needed to support flight and their long lifespans.
- Protostome 4mo agoI will let the experts continue from here :) This review is from 2020, i bet things have progressed since then https://pmc.ncbi.nlm.nih.gov/articles/PMC7169912/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7169912/
- scotty79 4mo agoIt's not so much a mitochondrial transplant, as it is fertilized egg nucleus transplant. Not just mitochondria are used from the third donor but their whole egg (sans nucleus). So unless a human might develop from a bat egg just from swapping out nucleus, which I'm sure it's not the case, super-powered batman must remain a fantasy.
- Protostome 4mo agoOh, so that's what you were aiming for, LOL there are many reasons for this chimera not to be viable, mitochondria co-evolves with the nuclear DNA, you can't just take a mitochondria from a totally different species
- scotty79 4mo agoBats are kinda close though. Maybe it would require just a handfuls specific adjustments to nuclear DNA, at most. Worth a shot if it could give us for example 2x multiplier for a healthy lifespan. Even getting 10 year old mice would be very cool.
- Schlagbohrer 4mo agoBatboy, real at last
- type0 4mo agoI don't, isn't this the recipe to get IRL Morbius?
- NoGravitas 4mo agoOr Man-Bat. https://en.wikipedia.org/wiki/Man-Bat https://en.wikipedia.org/wiki/Man-Bat