3 ms·
The fact that GLP-1 seems to have roles not just in satiety but that agonists seem to reduce other types of impulsiveness (e.g. gambling, shopping) is interesti
by krackers 3mo ago
The fact that GLP-1 seems to have roles not just in satiety but that agonists seem to reduce other types of impulsiveness (e.g. gambling, shopping) is interesting. That's not something you'd predict as a consequence, and perhaps is downstream of some gut-brain connection.
Of course we already manipulate brain chemistry in other more direct ways with antidepressants so perhaps any unwanted second-order effects could be minor in comparison to the profile of existing antidepressants .
- 9x39 3mo agoYeah, that's a good point. I hadn't heard about impulsiveness. I had read that taste preferences changed - e.g., salty, sweet, savory, fatty: https://pmc.ncbi.nlm.nih.gov/articles/PMC7105351/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7105351/ I've been watching developments on how GLP1s seem to go beyond just hunger/insulin response, even how they may affect symptoms of polycystic ovarian syndrome (PCOS), which is difficult on women who have it: https://academic.oup.com/ejendo/article/194/3/S25/8488941 https://academic.oup.com/ejendo/article/194/3/S25/8488941