3 ms·

Definium's LSD-based depression pill delivers strong late-stage results

23 points by bushwart 4mo ago

andsoitis 4mo ago
pretty exciting if this passes FDA approval. it's getting close.
- Acrobatic_Road 4mo ago
  I'm going to skip the line on this one.
amanaplanacanal 4mo ago
What is their dosing schedule? It says single dose, but how much are they giving?
- tclover 4mo ago
  It’s a single 100-microgram dose. It temporarily dampens the Default Mode Network (DMN), creating a "reset window" for the brain to rebuild its pathways. https://ir.definiumtx.com/news-events/press-releases/detail/232/definium-therapeutics-announces-positive-topline-results-from-phase-3-emerge-study-of-dt120-orally-disintegrating-tablet-odt-in-major-depressive-disorder https://ir.definiumtx.com/news-events/press-releases/detail/...
vortep 4mo ago
How do you do a double-blind with a drug that perceptibly changes your state of mind?
- RugnirViking 4mo ago
  I guess you do it anyway? the change in the state of mind is thought to be at least in part the mechanism of action, no? so if thats what makes it work, its good to test it against a non hallucinogen
- fragmede 4mo ago
  You can't, and it's a real problem for some people. Other people realize that, like testing the efficacy of parachutes by throwing two people off an airplane, one without a parachute; other people realize the double blind standard can't be applied but that the results aren't woo mystical astrology unfounded conclusions despite that.
  - thepotatodude 4mo ago
    academia is struggling to realize this
qsxfthnkp2322 4mo ago
What happens if I take 10? Oh wait. That layoff caused my health insurance to quit working. Oh well, can’t have any fun these days.
znpy 4mo ago
> Definium Therapeutics tab said a single dose of its LSD-based experimental pill significantly reduced symptoms of major depression Reminds me of Soma from “brave new world” by aldus huxley. We’re only missing a way to generate some pre-conditioned humans and we’re pretty much done (birthrates are already falling anyway, no need for malthusian practices).
- fragmede 4mo ago
  Do other antidepressants, of which there are many, remind you of Soma as well?
- evanjrowley 4mo ago
  Aldus Huxley was a proponent of LSD[0]. The Soma in his Brave New World is not meant to represent it. [0] https://daily.jstor.org/when-aldous-huxley-dropped-acid/ https://daily.jstor.org/when-aldous-huxley-dropped-acid/

23 points by bushwart 4mo ago

andsoitis 4mo ago

pretty exciting if this passes FDA approval. it's getting close.

Acrobatic_Road 4mo ago
I'm going to skip the line on this one.

amanaplanacanal 4mo ago

What is their dosing schedule? It says single dose, but how much are they giving?

tclover 4mo ago
It’s a single 100-microgram dose. It temporarily dampens the Default Mode Network (DMN), creating a "reset window" for the brain to rebuild its pathways. https://ir.definiumtx.com/news-events/press-releases/detail/232/definium-therapeutics-announces-positive-topline-results-from-phase-3-emerge-study-of-dt120-orally-disintegrating-tablet-odt-in-major-depressive-disorder https://ir.definiumtx.com/news-events/press-releases/detail/...

vortep 4mo ago

How do you do a double-blind with a drug that perceptibly changes your state of mind?

RugnirViking 4mo ago
I guess you do it anyway? the change in the state of mind is thought to be at least in part the mechanism of action, no? so if thats what makes it work, its good to test it against a non hallucinogen
fragmede 4mo ago
You can't, and it's a real problem for some people. Other people realize that, like testing the efficacy of parachutes by throwing two people off an airplane, one without a parachute; other people realize the double blind standard can't be applied but that the results aren't woo mystical astrology unfounded conclusions despite that.
- thepotatodude 4mo ago
  academia is struggling to realize this

qsxfthnkp2322 4mo ago

What happens if I take 10? Oh wait. That layoff caused my health insurance to quit working. Oh well, can’t have any fun these days.

znpy 4mo ago

> Definium Therapeutics tab said a single dose of its LSD-based experimental pill significantly reduced symptoms of major depression Reminds me of Soma from “brave new world” by aldus huxley. We’re only missing a way to generate some pre-conditioned humans and we’re pretty much done (birthrates are already falling anyway, no need for malthusian practices).

fragmede 4mo ago
Do other antidepressants, of which there are many, remind you of Soma as well?
evanjrowley 4mo ago
Aldus Huxley was a proponent of LSD[0]. The Soma in his Brave New World is not meant to represent it. [0] https://daily.jstor.org/when-aldous-huxley-dropped-acid/ https://daily.jstor.org/when-aldous-huxley-dropped-acid/