4 ms·

All of the "surprising" stuff they do is because they reduce neuroinflammation. Imo. As far as I can tell from the literature. I'm fairly sure that part of the

All of the "surprising" stuff they do is because they reduce neuroinflammation. Imo. As far as I can tell from the literature. I'm fairly sure that part of the reason they reduce neuroinflammation is because of pulmonary GLP-1 mechanisms. (Lung and brain are quite intimately connected, as is inflammation to the other two. As well as the gut. And… metabolism.) Neuroinflammation is very behavior-modifying. (Neuroinflammation kind of makes sense as an untamperable side-channel of information for neuronal processes – out of band; Protective. Can't think yourself to death.) There's tons of papers to read. You wouldn't believe how much accurate and correct and actionable and predictive scientific information exists that nobody reads. Read primary sources. Anyone can read. Don't let anyone tell you that you can't read. Least of all yourself.

CGMthrowaway 4mo ago
Why do you suggest the drop in violent behavior is a byproduct of neuroinflammation reduction, as opposed to being a byproduct of anhedonia which seems more obvious to me?
- AnthonBerg 4mo ago
  Good question!! thank you! Because of this paper: https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2018.00056/full https://www.frontiersin.org/journals/behavioral-neuroscience... (and having had twice the experience of autoimmune related illnesses making people close to me very aggressive until diagnosed and treated; and it was 1:1 always with things that made inflammation go up, aggression went up. In retrospect. And the opposite: things that reduced aggression always have an inflammation-reducing aspect)
- DANmode 4mo ago
  Because anhedonia feels like a condition/symptom, not a diagnosis.
mieubrisse 4mo ago
Do you have any recommendations for literature you like? (My experience in eye science matches yours - the literature is WAY ahead of what people believe)
- AnthonBerg 3mo ago
  Belated! Been thinking about this since… 6 days ago!, haha and! This: "Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor" https://www.pnas.org/doi/10.1073/pnas.0603119103 https://www.pnas.org/doi/10.1073/pnas.0603119103 (We are all coated in urocanic acid. Right now. We secrete it. ahhaha. what!! And. It isomerizes in UV light and plops into the 5-HT2A receptor and downregulates inflammation.)

CGMthrowaway 4mo ago

Why do you suggest the drop in violent behavior is a byproduct of neuroinflammation reduction, as opposed to being a byproduct of anhedonia which seems more obvious to me?

AnthonBerg 4mo ago
Good question!! thank you! Because of this paper: https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2018.00056/full https://www.frontiersin.org/journals/behavioral-neuroscience... (and having had twice the experience of autoimmune related illnesses making people close to me very aggressive until diagnosed and treated; and it was 1:1 always with things that made inflammation go up, aggression went up. In retrospect. And the opposite: things that reduced aggression always have an inflammation-reducing aspect)
DANmode 4mo ago
Because anhedonia feels like a condition/symptom, not a diagnosis.

mieubrisse 4mo ago

Do you have any recommendations for literature you like? (My experience in eye science matches yours - the literature is WAY ahead of what people believe)

AnthonBerg 3mo ago
Belated! Been thinking about this since… 6 days ago!, haha and! This: "Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor" https://www.pnas.org/doi/10.1073/pnas.0603119103 https://www.pnas.org/doi/10.1073/pnas.0603119103 (We are all coated in urocanic acid. Right now. We secrete it. ahhaha. what!! And. It isomerizes in UV light and plops into the 5-HT2A receptor and downregulates inflammation.)