Isolation and depression for sure. If you work remotely, having a friend group or other social activities outside your house is probably all the more important.

Isolation and depression for sure. If you work remotely, having a friend group or other social activities outside your house is probably all the more important. As someone who mostly socialises online, I can go many, many days without really talking to anyone or interacting with them in any meaningful way. It's also potentially hazardous for your health if you're not careful with your diet/don't stay in shape. Being in an office definitely limits your opportunities to eat unhealthy food, and (in a walkable city at least) forces you to walk at least a certain distance every day. I suspect this is why a lot of software engineers nowadays seem a lot more interested in going to the gym or sticking to a healthy diet than they used to.