Just as it was before, but less-so now, it all comes down to who you want viewing your site. There is no single rule about what your site needs to adhere to, no

Just as it was before, but less-so now, it all comes down to who you want viewing your site. There is no single rule about what your site needs to adhere to, nor a single set of best practices that are appropriate for everything. If you are concerned about your users, a lot of people these days are basically sacrificing accessibility for a better user experience for the non-visually impaired users with a recent browser. That is a bigger problem than web-safe colors by far. Web accessibility may eventually become subject to the ADA: http://www.ada.gov/ http://www.ada.gov/