4 ms·
Alzheimer's patient gets back speech, bladder control and memory in drug trial
- comrade1234 4mo agoNew York Post? Yeah I don't think so...
- sendmarsh 4mo agoIt did a relatively accurate report on the original Frontiers paper: https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1813281/full https://www.frontiersin.org/journals/neuroscience/articles/1...
- hentrep 4mo agoHere’s the original manuscript: https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1813281/full https://www.frontiersin.org/journals/neuroscience/articles/1...
- dwroberts 4mo ago“Administer 5g psilocybin”. This experiment seems really awful to me. Don’t get me wrong, psychedelics can be great but the idea of giving them to someone with an already severely fractured mental state seems unethical, and the gains they talk about are almost certainly going to be temporary in a way that is going to prolong their suffering.
- propaganja 4mo agoI understand where you're coming from, but strongly disagree with your conclusions. A patient with severe Alzheimer's effectively has nothing to lose, and the same goes for the patient's loved ones. Moreover, I'd argue the risks involved are minor/short-lived, while the gains are potentially priceless, even if temporary.
- Aboutplants 4mo agoFirst of all 5mg is a standard medical dosage for this medicine and isn’t likely to produce horrible experiences that you would get with much larger doses. Second, you think it’s more ethical to let a patient suffer? Are you against emergency surgeries where a patient is unconscious after a car accident?
- dwroberts 4mo agoThe dose in the paper is 5 grams, not mg > Second, you think it’s more ethical to let a patient suffer? Are you against emergency surgeries where a patient is unconscious after a car accident? My concern is that this induces more suffering. They are going to gain lucidity and then lose it again. That must be deeply distressing (for the family/relatives too). Can’t imagine that psychedelics help with the state of psychosis/hallucinations that advanced Alzheimer’s patients already experience too
- sendmarsh 4mo agoFrom the Frontiers paper: "The patient received 5 g of orally administered psilocybin-containing mushrooms (Enigma strain". i.e., a standard dose of 5g of mushroom.
- dwroberts 4mo agoI’m assuming you’ve never taken mushrooms before (on average there is probably ~10mg psilocybin per dried gram, so 5g is 50mg which is on the high end of dosing, definitely not ‘standard’)
- porksoda 4mo agoI just got to the bottom of your argumentative thread and I just got to say: "says you".
- jfyi 4mo agoWe don't know they were dried. We do know the strain is a particularly potent one that grows in a fashion that might not lend itself to normal water concentrations. Really though, weren't you the one conflating mushroom dosages with those of pure psylocibin a moment ago? I find it difficult to believe someone with more than incidental experience would make that mistake.
- poulpy123 4mo agoI'm quite suspicious of it. Psilocybin has potential for brains that do not work properly, but Alzheimer destroys the brain