That’s probably because many opioids are ligands of both mu and kappa receptors. Menthol, for example, only activates the kappa receptor: accidentally overdosi

That’s probably because many opioids are ligands of both mu and kappa receptors. Menthol, for example, only activates the kappa receptor: accidentally overdosing on pure menthol felt to me like immediate doom was approaching and nothing would ever again be fine. I don’t eat anything menthol-flavored any more. It seems like an operant conditioning agent masquerading as a flavor.