2 ms·
Kappa-opioid receptor activation causes a person to feel intense dissociative dysphoria. Pretty much the opposite of why people use opioids.
by cluckindan 5mo ago
Kappa-opioid receptor activation causes a person to feel intense dissociative dysphoria. Pretty much the opposite of why people use opioids.
- cbonanno 5mo agoI don’t think this is true. Opioid use has been associated with numerous psychiatric symptoms, including dissociative symptoms. https://corescholar.libraries.wright.edu/psychiatry/62/ https://corescholar.libraries.wright.edu/psychiatry/62/
- cluckindan 5mo agoThat’s probably because many opioids are ligands of both mu and kappa receptors. Menthol, for example, only activates the kappa receptor: accidentally overdosing on pure menthol felt to me like immediate doom was approaching and nothing would ever again be fine. I don’t eat anything menthol-flavored any more. It seems like an operant conditioning agent masquerading as a flavor.