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Retatrutide is incredible in a mind altering way. I know 4 people on it, including myself. And all just love the way it makes you feel. You just don’t want to e
by mchusma 5mo ago
Retatrutide is incredible in a mind altering way. I know 4 people on it, including myself. And all just love the way it makes you feel. You just don’t want to eat as much and you want to eat healthier. As far as I can tell, that is it. While I’m nervous there could be long term side effects, I think the health benefits of being at a healthy weight mean that for probably 50% of the developed world they would benefit from it.
Looking forward to more formal studies though!
- icameron 5mo agoDoes it alter you mind more than just your appetite for healthy food like you said? Is there a buzz or general mood lift as well?
- cj 5mo agoIf there's any mental effect, it's most likely from eating less food (and most likely healthier food) and feeling better because of that. It doesn't increase your appetite for healthy food. It will punish you for eating bad food. "Don't eat that steak, you're going to have crazy stomach pain tomorrow if you do!"
- stavros 5mo agoThat's not my experience with tirzepatide. When it worked for me (which was a brief period, admittedly), it kind of turned me off fatty foods, and I wouldn't want to have pizza, for example, but I'd crave a chicken breast and boiled potato, or salad. When it didn't work, one of the failure modes was that I still craved fatty/fried food, but I got terrible stomach pain from it, which is the worst of both worlds. If I'm still going to be unable to resist food, I don't want to be punished for it any more than I already am by being overweight!
- cj 5mo ago> When it didn't work, one of the failure modes was that I still craved fatty/fried food, but I got terrible stomach pain from it I saw this was a feature, not a bug.
- stavros 5mo agoFor me, it was definitely a bug, because my issue is I can't restrain myself. I don't lose weight, I just get pains. If I could restrain myself, why do I need the medication?
- taejavu 5mo agoWhat’s wrong with eating steak? Biologically I mean, not ethically.
- fintech_eng 5mo agoAbsolutely nothing, if you only eat a few ounces. But a lot of places will server you a 12 oz ribeye steak which has 900 calories all by itself. Add on a side of french fries and a sugary beverage and you get a days worth of calories in a single sitting. When you are on a GLP medication, commonly your digestion slows and will make you really prone to constipation and acid reflux. I've learned to eat just 3-6 ozs when I do steak, and generally opt for the veggies instead of the potatoes now. Feel much better in the morning.
- tptacek 5mo agoA 12oz ribeye is a pretty generous serving; it's not something that sneaks up on you. The surprising thing for me, having settled into a ~1400kcal budget, is how tricky it is to hit protein goals. You go into this thinking it'll be like going low-carb, you'll just eat a lot of beef, but the fun cuts are not efficient protein delivery vehicles. Hitting the kcal budget is effortless; getting the protein in, not so much.
- fintech_eng 5mo agoSame! Keeping a small stock of these has helped me a lot with that: https://fairlife.com/core-power/chocolate-protein-shake-42g/ https://fairlife.com/core-power/chocolate-protein-shake-42g/
- taejavu 5mo agoYeah I think the fries and sugary beverage would be contributing to the “crazy stomach pain” a lot more than the steak. But the person I’m replying to made no mention of those things..
- fintech_eng 5mo ago
- stavros 5mo agoUnfortunately, my experience with tirzepatide doesn't make me hopeful: It either gave me terrible diarrhea and sulfur burps, or it did nothing at all, even on 15mg. Hopefully retatrutide is different, but I'm not holding my breath. It did work for around two weeks, though, and it was great. I constantly felt mildly carsick, so I didn't really want to eat anything, but also didn't have much trouble eating my macros.
- cj 5mo agoHow did you get to 15mg and only had it working for 2 weeks? The starting dose is 2.5mg and it takes many months to titrate up to 15mg. Most people never get to 15mg. I've read hundreds of anecdotal experiences from people on these drugs, and haven't encountered anyone taking 15mg without success.
- stavros 5mo ago> How did you get to 15mg and only had it working for 2 weeks? Shrug, it's a mystery to me as well. It did take many months to get to that point.
- zemvpferreira 5mo agoSorry to hear that. As a counterpoint for the peanut gallery I've been on tirzepatide for 5 months and lost 15 kg in the first 3 months, never going past a 1.25mg dose. I've only creeped up to 3mg since and keep losing around 0.3 kg per week. No side effects except for super mild nausea every now and then. I plan to stay at a similar or lower dose for the next couple of years. I had the good fortune of responding well and being at a great starting point: despite being 40% body fat I exercised a lot and had great labs to begin with. Anecdotally I've found starting metabolic health to make a huge difference in dose response.
- stavros 5mo agoThanks, everyone else I know who's tried it has had great results, I guess I'm just unlucky :/
- 5mo ago
- nose 5mo agoHow is everyone purchasing Retatrutide at this moment? It's still in phase 3 trials, and I keep hearing of people being on it. Not really seeing safe options with proper lab testing. Other pharmaceuticals at the phase 3 stage (such as Buntanetap for Parkinson's disease) are super difficult to get, even with the right to try exemption in the US.
- antinomicus 5mo agoYeah, I hear everyone talk about it like it’s just super easy to get…
- QuantumGood 5mo agoIndependent lab test results from multiple vendors, e.g. https://www.finnrick.com/products/retatrutide https://www.finnrick.com/products/retatrutide
- deleted 5mo ago[deleted]
- bsamuels 5mo agothey buy it from research peptide vendors
- elteto 5mo agoWellness/Health clinics sourcing from China or compounding pharmacies, which themselves source the ingredients from China.
- QuantumGood 5mo agoStart by looking at independent lab test results from multiple vendors, e.g. https://www.finnrick.com/products/retatrutide https://www.finnrick.com/products/retatrutide
- SomaticPirate 5mo agohttps://www.ft.com/content/b15407bd-7b86-45c3-9780-0c92117ccbfb?shareType=nongift https://www.ft.com/content/b15407bd-7b86-45c3-9780-0c92117cc... They are buying from Chinese dealers. And sadly, as with most GLP-1s they likely will need to take them for the rest of their life or suffer some incredible rebound weight loss/ negative health effects. These medications are incredible if you are overweight and need them. But they are not a panacea. Also arguably buying these drugs from Chinese dealers means there is no recourse if you get a bad batch. There is a pseudo testing setup around Finnrick but talk to anyone with a PhD in biochemistry and there are numerous ways these molecules can be improperly manufactured. Surprised to see so many on HN being relatively careless with their heath
- jfreds 5mo agoI tried semaglutide and while it was effective for losing weight, it made working out impossible (felt exhausted and very sick as soon as hr went up) and it made hangovers awful. Is retatrutide any different?
- the_real_cher 5mo agoI got food poisoning on a glp2 and it was the worst I've ever felt in my life for like a week because it it slows the digestion. it was an edge case I had not considered.
- zulux 5mo agoAlso, when you need to vomit, GLP1 still makes your body think there's food left to vomit, and you can wind up retching for quite a while.
- the_real_cher 5mo agoNever again!
- ASalazarMX 5mo agoI'm surprised your doctor didn't recommend a laxative, because they know it slows digestion.
- tsol 5mo agoHad the same issue. With reta I have more energy than normal and workout even more than usual. I get great workouts despite eating around 1400 calories a day. I don't wanna act like it's without flaws but I gotta say it does it's job very well
- asdff 5mo agoNow that the drug has shown you what a more appropriate portion is, do you think you can manage that on your own without the drug?
- gpt5 5mo agoAll research points to a "no" answer - weight is regained, and quickly. Which helps explain why obesity is so prevalent - it is something in the brain's chemistry.
- asdff 5mo agoWeight would only be regained if you start eating more, no? I would think that would be hard to do if you've already seen what appropriate portions are.
- OkayPhysicist 5mo agoYou seem to have a fundamental misunderstanding of what GLP-1 agonists help with. In simple terms, they make you less hungry. If you stop the drugs, it's not surprising you go back to being hungry. It would be a miracle drug if you didn't. People, on average, eat until they're no longer hungry. Problem is, there's only a loose relationship between your caloric needs and your hunger response. That's how you end up with underweight people who are trying to put on muscle saying they can't possibly eat any more and still can't put on weight, while having overweight people who eat twice as much as that guy and have to actively choose not eat more. Both people can make a conscious choice to disobey their signals, just like how you can choose to hold your hand to a hot stove. But it takes a lot of energy to keep up that willpower. Effective weightloss drugs solve that problem, by treating the actual problem: the hunger.
- asdff 5mo agoI don't misunderstand. I understand they stop you from feeling as hungry. That is why it is even more perplexing. Eating until you are no longer hungry isn't how most people eat I'd say. Most people eat a given quantity of food. A plate of food. A bowl of soup. An entree with the provided side perhaps. People don't generally order food, eat it, and order more food. Maybe they do I guess, but I haven't seen it personally. I mean I think a lot of people could shove a dozen hotdogs down their gullet if they wanted to, but that reaction isn't a typical expectation. Plus once you've seen normal portions, surely you'd realize when you are going beyond those. Speed of eating might also be an underrated factor in all this. Stretching out ones meals and slowing down the pace might lead to satiety triggers coming before the meal is done, whereas if one scarfs down the plate before that signal happens, well, one already scarfed down the plate and might be working into the next before those signals hit. This meta analysis suggests this is a possibility (1). 1. https://pmc.ncbi.nlm.nih.gov/articles/PMC8156274/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8156274/
- mtdewcmu 5mo ago>> Retatrutide is incredible in a mind altering way >> and all just love the way it makes you feel Maybe it will turn out to be an antidepressant as well. That would be quite a coup.
- rickydroll 5mo agoThere have been some hit pieces on Retatrutide that claim it blunts emotions, period. It was characterized as, "falling out of love with someone." Have you noticed anything like that?