@work we have done a lot of this kind of validations using a custom Tcl script, and luckily we have avoided to be blacklisted till now. Maybe it's due to the fa

@work we have done a lot of this kind of validations using a custom Tcl script, and luckily we have avoided to be blacklisted till now. Maybe it's due to the fact that validation requests come from an IP address marked as MX for the domain of the sender email address. Anyway not all SMTP servers are RFC compliant, they respond with a 2XX code to a "RCPT TO" even if user/mailbox doesn't exists. The same thing applies also if the SMTP server is acting as a relay and has no immediate access to the delivering system.