3 ms·
Low-Dose Aspirin Usage for Primary Prevention Has Fallen by >50% Since 2018
- Herodotus38 5mo agoGreat to see an example of concrete evidence that physicians made changes when the evidence showed a change was needed.
- nikolay 5mo agoThis "evidence" is highly questionable. There's other evidence, i.e., that taking aspirin with DGL or vitamin C does not damage the stomach lining, have led to new formulations decades ago. In fact, high doses of aspirin have been sold in Europe combined with vitamin C for as long as I remember - Aspirin C by Bayer and Upsarin C by UPSA. There's other evidence, too, that aspirin protects against cancer.
- teslabox 5mo agoMy understanding is the bleeding risk associated with aspirin can be addressed by taking Vitamin K.
- nikolay 5mo agoI haven't heard about it, but the combo would have a synergistic effect as they both address different coagulation pathways. I take them together for other reasons - I take vitamin K (K1, and K2 in MK-4 and K2 MK-7 forms) to direct calcium to the bones, not to the tissues, and, of course, anticollagulation. For the latter, I also take Nattokinase, but the main reason I take Aspirin is its protection against cancer.
- Herodotus38 5mo agoSounds like you have additional and better evidence than the USPTF that made the changes in aspirin for primary prevention. They do have a method to give feedback, and based on my experience a person will respond to you personally. I suggest you submit your information to them. https://www.uspreventiveservicestaskforce.org/uspstf/public-comments-and-nominations https://www.uspreventiveservicestaskforce.org/uspstf/public-...
- aaron695 5mo ago[dead]
- OutOfHere 5mo agoLow-dode aspirin wrecks the stomach or small intestine anyway in many individuals, irrespective of its form. This strikes a lot sooner than internal bleeding. Both the chewable and the enteric-coated forms cause this injury at separate locations.
- nikolay 5mo agoIt doesn't, as it doesn't dissolve in the stomach, thanks to its enteric coating.
- cucumber3732842 5mo ago>in many individuals, So then why are we not working to determine which individuals it is suitable for? What is the alternative to aspirin for this use case and who benefits?
- OutOfHere 5mo agoOne just finds out by trial and error, although the injury can take many months to manifest, and is slowly reversible upon cessation. As for the safer pharmaceutical alternative, clopidogrel is it, again in a sufficiently low dose, but it is not OTC.
- clumsysmurf 5mo agoIts probably best to talk to your doctor about a CAC score. I don't know if its possible to tell stable vs unstable plaque yet, but a higher CAC score may benefit from aspirin.
- red-iron-pine 5mo agoguessing ozympic, statins, and stomach staples + pretty reliable stats about causing internal bleeding
- vlod 5mo agoRegarding bleeding risks. Is this due to the stomach being empty? Does taking it at the end of a large meal better?
- robocat 5mo agoUS study. From link: Patients with conditions that would indicate aspirin use for secondary prevention (such as coronary artery disease, prior stroke, or peripheral artery disease) as well as those for whom aspirin was contraindicated due to allergy or pregnancy were excluded. So they excluded "coronary artery disease, prior stroke, or peripheral artery disease" which covers most people that might be prescribed aspirin? Who's left?