Well, from the comments we see: -possible disruption of gut microbiome -possible trigger of migraines as well as from other places: -those with phenylketonu

Well, from the comments we see: -possible disruption of gut microbiome -possible trigger of migraines as well as from other places: -those with phenylketonuria (PKU) must avoid it -there are concerns that aspartic acid which is produced "can act as an excitotoxin, overstimulating nerve cells and potentially leading to neuronal injury and cell death" with chronic exposure or high doses -potentially carcinogenic -no nutritional value (thus no "need" to consume it) Fruit, honey, or maple syrup in contrast are natural without some of these concerns in the same way