8 ms·
you suggest additional drinking methanol when you're "normally" drunk?? that's dangerously counterfactual.
by froh 6mo ago
you suggest additional drinking methanol when you're "normally" drunk?? that's dangerously counterfactual.
- dnnddidiej 6mo agovice versa > Ethanol is the most commonly used antidote to block the metabolising of methanol. Ethanol works by competing with the metabolic breakdown of methanol, thereby preventing the accumulation of toxic byproducts. MSF: https://methanolpoisoning.msf.org/en/for-health-professionals/ https://methanolpoisoning.msf.org/en/for-health-professional... I can see the ambiguity of my comment. I was trying to phrase as a riddle but can be interpreted both ways.
- adzm 6mo agoNo, ethanol is an antidote to methanol
- hilbert42 6mo agoWhere's the authority on that? Ethanol can be used as a temporary measure in methanol poisoning as it temporarily outcompetes methanol in the metabolic process. So it's only useful until proper medical help arrives when better alternatives such as fomepizole are administered. Even then there is no guarantee of success. Methanol is still metabolized to dangerous formaldehyde and formic acid by the liver's alcohol dehydrogenase. The logic of giving ethanol or fomepizole is to slow down the rate of production methanol's dangerous metabolic byproducts so less damage is done, nevertheless those dangerous metabolites are still produced. Ethanol's first-pass metabolite is acetaldehyde and it is still toxic but not to the same degree as those of methanol. It is incorrect to say ethanol is an antidote for methanol poisoning. Using ethanol is a last-ditch stand to try and take some minor control of an otherwise out of control situation. There's nothing subtle about it—it's a blunderbuss approach that often doesn't work well because replacing one poison with a less toxic one is a pretty hit-and-miss process. Antidotes counteract poisons, that's not what happens when you give ethanol in methanol poisonings.
- dnnddidiej 6mo agoIt is technically an antidote though. Based on the definition of antidote.
- btreecat 6mo agoWhere are the sources on your claims that ethenol is only a temporary or last ditch treatment?
- hilbert42 6mo agoSuggest you read the link in my reply to pessimizer.
- btreecat 6mo agoIf you don't want to provide a link and quote to the source, I'm going to treat it as it's unsourced. If you want to claim the link and source are in another castle, I'm not playing games. https://pmc.ncbi.nlm.nih.gov/articles/PMC1306022/ https://pmc.ncbi.nlm.nih.gov/articles/PMC1306022/ > A 10% ethanol solution administered intravenously is a safe and effective antidote for severe methanol poisoning. Ethanol therapy is recommended when plasma methanol concentrations are higher than 20 mg per dl, when ingested doses are greater than 30 ml and when there is evidence of acidosis or visual abnormalities in cases of suspected methanol poisoning.
- deleted 6mo ago[deleted]
- hilbert42 6mo agohttps://www.mdpi.com/2305-6304/12/12/924 https://www.mdpi.com/2305-6304/12/12/924. Point 7.
- btreecat 6mo agoUnder > 7.4. Antidotes and Elimination Enhancement > 7.4.2. Ethanol A therapeutic blood ethanol level of about 22 mmol/L (100 mg/dL) is recommended. ... >If ethanol was coingested with methanol and the blood ethanol level initially was >22 mmol/L (100 mg/dL), the bolus dose of ethanol can be skipped. It's like you didn't even read your own source. They are calling it recommended for certain conditions, and saying you can skip parts of treatment for co-ingestion! Then in the conclusions section > Despite its extensive use, methanol poisoning remains a critical public health concern globally, often resulting from accidental or intentional ingestion and outbreaks linked to contaminated beverages. They've called out contaminated beverages, not outputs of distillation. You've been had by misinformation and now you're peddling lies.