2 ms·

If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes f

by stouset 7mo ago

If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.

JumpCrisscross 7mo ago
Do you have a link to those data showing GLP-1 agonists are ineffective?
- rzmmm 7mo ago
  I emphasize it's like the drug disulfiram: Very effective as long as patients take the full dose, but the lack of real-world efficacy stems from the difficulty in adhering to the treatment. This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829779 https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
  - JumpCrisscross 7mo ago
    > the lack of real-world efficacy stems from the difficulty in adhering to the treatment Do you have a source for this "lack of real-world efficacy"? > This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years "With a with a median on-treatment weight change of −2.9%" [1]. Of those who discontinued and experienced "weight gain since discontinuation," they were "associated with an increased likelihood of GLP-1 RA reinitiation." I'm genuinely struggling to see how this source shows real world inefficacy. In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to. Out of curiosity, what sources lead you to believe this? > it's like the drug disulfiram Have clinicians made this connection? [1] https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829779 https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
- stouset 7mo ago
  You didn’t come here with data. You came here with anecdotes and asserted that they were conclusive.

2 ms·

If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes f

by stouset 7mo ago

If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.

JumpCrisscross 7mo ago
Do you have a link to those data showing GLP-1 agonists are ineffective?
- rzmmm 7mo ago
  I emphasize it's like the drug disulfiram: Very effective as long as patients take the full dose, but the lack of real-world efficacy stems from the difficulty in adhering to the treatment. This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829779 https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
  - JumpCrisscross 7mo ago
    > the lack of real-world efficacy stems from the difficulty in adhering to the treatment Do you have a source for this "lack of real-world efficacy"? > This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years "With a with a median on-treatment weight change of −2.9%" [1]. Of those who discontinued and experienced "weight gain since discontinuation," they were "associated with an increased likelihood of GLP-1 RA reinitiation." I'm genuinely struggling to see how this source shows real world inefficacy. In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to. Out of curiosity, what sources lead you to believe this? > it's like the drug disulfiram Have clinicians made this connection? [1] https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829779 https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
- stouset 7mo ago
  You didn’t come here with data. You came here with anecdotes and asserted that they were conclusive.