4 ms·
> My patient is refusing a drug studied in 170,000 people because of side effects that a 124,000-person analysis just confirmed do not exist — while injecting a
by diath 6mo ago
> My patient is refusing a drug studied in 170,000 people because of side effects that a 124,000-person analysis just confirmed do not exist — while injecting a compound studied in 14 humans, from unregulated sources, based on the recommendation of someone who profits from selling it. She’s probably not the only one. And those using it believe they are “doing their own research.”
Ok, and? At worst you waste a couple hundred dollars and deem the alternative therapy not worth it and go back to your doctor but I know dozens of people at my gym that used BPC 157 and TB 500 that fixed their chronic tendon/joint issues within weeks of starting the therapy that physios couldn't fix for years.
- orf 6mo agoYou know dozens of people from a single place that have chronic tendon/joint issues?
- ted_dunning 6mo agoSure. He says that they commonly use steroids. It's no wonder they have degenerative joint disease.
- diath 6mo agoYes? These types of injuries are common among bodybuilders and powerlifters.
- kube-system 6mo agoPfft -- they're common among anyone over 30 who exercises!
- JumpCrisscross 6mo ago> they're common among anyone over 30 who exercises They shouldn't be. If someone has chronic tendon or joint issues, that's something to discuss with a doctor and a trainer.
- defmacr0 6mo agoIt's very common when people start doing a new exercise regimen. Muscles can become significantly stronger on a timescale of months, while an equivalent increase in the strength of tendons happens on a timescale of a few years. Once somebody has a few years of training under their belt, muscle mass gains are way slower and the capacity of the ligaments will have caught up and these issues go away. However, with bodybuilders and strength athletes these problems can easily come back once anabolic steroids are involved and give big muscular gains without the same level of adaptations in connective tissues.
- kube-system 6mo agoI think we are, and I'd presume that's why sports medicine centers are so common.
- cheald 6mo agoHang out at a BJJ or MMA gym for a bit, and you'll find plenty. Peptides are really popular in combat sports circles, with good reason.
- cgh 6mo agoYou should hang out at a climbing gym sometime. There is nothing that unites climbers more than injury talk.
- phil21 6mo agoI don't doubt it. You make casual friends sometimes at certain gyms, especially if any sort of sports are involved like tennis or even group classes. I am a super introvert and know at least half a dozen folks with such issues, more if you include my close friend group. Any place that has a lot of physically active people stressing their limits a bit is going to have a lot of injured folks over a decent period of time. And of course it gets talked about quite a lot, since it limits performance and ability. My trainer knows I have a chronic shoulder issue, and an adductor issue at the moment I'm working through that we need to avoid stressing too much. The few other folks who tend to work out around my schedule know of this, and I know of theirs. Not very uncommon really.
- LMYahooTFY 6mo agoIt's often part of the life if you're lifting competitively.
- aaarrm 6mo agoMy partner's grandfather died of cancer because when he was having pains they believed their homeopathic medicine would work. When he finally when in to see a real doctor it was too late. If he had gone in earlier, he would been able to have a chance. This is not a rare occurrence for these types.
- phil21 6mo agoWhy would you stop going to a real doctor though? It's not one or the other. I'm very on the fence over BPC-157/TB500, I really want to see some actual clinical trials ran on it. I have a feeling the effects are overstated, but I also have had a number of "insider" conversations where I know these and other compounds are very much being utilized in pro athlete injury recovery programs. Those athletes certainly are getting state of the art medical care via traditional sources, plus elite level physio therapy - so it's hard to say if the illicit injury recovery drugs are doing much or not.
- cgh 6mo agoI don’t think either of those are patentable so I doubt you’ll see studies or trials any time soon. A lot of strength athletes at all levels, not just elite, are absolutely convinced of their efficacy and their usage sometimes seems as common as ibuprofen.
- kibibu 6mo ago> I know dozens of people at my gym I don't think I even know dozens of people, full stop, let alone well enough to talk to them about their peptide use.
- diath 6mo agoI go to a gym that has IFBB pros and people competing on elite powerlifting level, steroid and peptide use is an every day chit chat topic.
- meiuqer 6mo agoThat does not seem like an environment we should use to determine if the rest of the world should take a substance lol
- diath 6mo agoBut I'm not saying everyone should be taking these peptides, I'm not coercing anyone, my original point was that people like the author of the article should mind their own business what other people choose to do with their own bodies.
- simmerup 6mo agoThe group of people that seem to be dying in their 30s of heart failure then
- rs_rs_rs_rs_rs 6mo agoHe's the guy that's selling them peptides.
- dc396 6mo ago> Ok, and? According to our new AI overlords, a short synopsis of potential risks of BPC 157 based on mechanistic and animal work to date (don't know human risks because there haven't been sufficient clinical studies): * Possible pathologic angiogenesis (abnormal blood‑vessel growth), which theoretically could support tumor growth or inflammatory and autoimmune processes. * Modulation of nitric‑oxide pathways that, at high levels, might contribute to anemia, altered drug metabolism (CYP enzyme activity), and possibly neurodegenerative processes in theory. * Concerns that its pro‑healing, pro‑growth signalling (e.g., FAK–paxillin) could encourage cancer spread if malignant cells are already present; this remains theoretical, with no proof in humans. * Possible liver and kidney toxicity suggested in some commentary and extrapolated from preclinical work, but not well characterized in people. * Immune reactions or allergic responses, including fevers, rash, hives, muscle aches, or systemic inflammatory responses These do not appear to be results that would appear overnight. It would be "nice" if the folks injecting random shit into their bodies also disclaimed any subsequent medical intervention as a result of said shit, but that I suspect that's unlikely.
- rzmmm 6mo agoMy total layman view is that powerful drugs often have powerful side effects.
- XorNot 6mo agoThat's because you grew up in a society still deeply coded to puritan moral viewpoints. People for so upset that GLP-1 has no long term side effects. There's still the crowd completely sure everyone will get HyperCancer in 10 years or something (they won't).
- rzmmm 6mo agoI'm glad we have GLP-1, and I don't think there are really major side effects. But they are ineffective outside clinical trial setting for treating obesity. It seems to be like treating alcoholism with disulfiram: it's a miracle in clinical trials but in the real world the patients just lower the doses or discontinue treatment after 1-2 years and go back to their old habits.
- nmbrskeptix 6mo ago[dead]
- Nursie 6mo ago> At worst you waste a couple hundred dollars At worst you inject unknown substances into your bloodstream that could do more or less anything.
- nmitchko 6mo agoI used those two in combination to fix pain after 3x surgeries to repair a torn pec + infection. They work and helped me heal from being at a 3/10 constant pain down to baseline. Not something I would do at any point for fun. But anecdotally, it's materially better than other alternatives offered/available.