In 20 years I expect basically all of these to move to web-based interfaces and away from thick clients. You're already seeing graphics heavy use cases like CAD

In 20 years I expect basically all of these to move to web-based interfaces and away from thick clients. You're already seeing graphics heavy use cases like CAD do this (Onshape has been hugely popular and is cloud native on Linux). Even behemoths like SAP are increasingly web enabled through fiori.