12 ms·

I'd argue that the results might not be from the drugs but from the fact that they were heavily monitored by other humans. It's not the drugs that people with

I'd argue that the results might not be from the drugs but from the fact that they were heavily monitored by other humans. It's not the drugs that people with high anxiety need, it's people giving them attention and caring for them. These experiments need a control where they just take the drug and they don't have medical staff around.

throwaway12pol 7mo ago
Isn't that basically the same as them using a placebo? If just care has the same effect, then surely heavily monitoring them while providing a placebo drug should work.
- cassepipe 7mo ago
  The problem is you can very obviously tell that you have a placebo because nothing is happening. Some studies mitigate that issue by giving a microdose but then maybe only the microsose is necessary? It seems like a hard problem
  - cluckindan 7mo ago
    Such studies typically use an active placebo, such as methylphenidate.
- butlike 7mo ago
  But that doesn't test if the LSD helps in a non-clinical setting, only that the monitoring and attention helps
lacunary 7mo ago
"In this phase 2b, multicenter, randomized, double-blind, placebo-controlled study of 4 dose levels of MM120 that included 198 adults with generalized anxiety disorder, the primary outcome of a dose-response relationship for change in Hamilton Anxiety Rating Scale score at week 4 was statistically significant."
IAmBroom 7mo ago
You are fabricating a lot of details about the study to come to that conclusion. If only there were experts on the ground, designing the experiment, who could plan to avoid such interfering variables.
adammarples 7mo ago
The control is where you have the medical staff around but not the drug. I believe placebo control groups are pretty common.
motoxpro 7mo ago
This is exactly what the placebo is for. Same attention and care, no drug.
abrookewood 7mo ago
That's why we have placebos ... and double-blind studies ...

throwaway12pol 7mo ago

Isn't that basically the same as them using a placebo? If just care has the same effect, then surely heavily monitoring them while providing a placebo drug should work.

cassepipe 7mo ago
The problem is you can very obviously tell that you have a placebo because nothing is happening. Some studies mitigate that issue by giving a microdose but then maybe only the microsose is necessary? It seems like a hard problem
- cluckindan 7mo ago
  Such studies typically use an active placebo, such as methylphenidate.
butlike 7mo ago
But that doesn't test if the LSD helps in a non-clinical setting, only that the monitoring and attention helps

lacunary 7mo ago

"In this phase 2b, multicenter, randomized, double-blind, placebo-controlled study of 4 dose levels of MM120 that included 198 adults with generalized anxiety disorder, the primary outcome of a dose-response relationship for change in Hamilton Anxiety Rating Scale score at week 4 was statistically significant."

IAmBroom 7mo ago

You are fabricating a lot of details about the study to come to that conclusion. If only there were experts on the ground, designing the experiment, who could plan to avoid such interfering variables.

adammarples 7mo ago

The control is where you have the medical staff around but not the drug. I believe placebo control groups are pretty common.

motoxpro 7mo ago

This is exactly what the placebo is for. Same attention and care, no drug.

abrookewood 7mo ago

That's why we have placebos ... and double-blind studies ...