4 ms·
AIUI, all such results are because the FDA has given up since aduhelm and said "well, if it clears amyloid, that's as good as slowing Alzheimer's, right?" despi
by jcranmer 8mo ago
AIUI, all such results are because the FDA has given up since aduhelm and said "well, if it clears amyloid, that's as good as slowing Alzheimer's, right?" despite the actual results on Alzheimer's progression being largely negative.
- riskassessment 8mo agoFor what it's worth, early statins were originally cleared based only on the evidence that they lower cholesterol without longer term studies showing a reduction in mortality. Of course there is now plenty of evidence showing statins improve overall endpoints.
- simulator5g 7mo agoThat doesn't sound like the same thing at all.
- Auracle 7mo agoThat’s true. Similarly, there were other drugs that lowered cholesterol that didn’t show a significant reduction in coronary events. As we later learned, it’s not nearly as simple as “cholesterol bad.”
- deleted 7mo ago[deleted]