Two folk who set the direction of the modern world - Isaac Newton and Charles Darwin. https://historycollection.com/16-examples-of-the-madness-of-sir-isaac-new

Two folk who set the direction of the modern world - Isaac Newton and Charles Darwin. https://historycollection.com/16-examples-of-the-madness-of-sir-isaac-newton/ https://historycollection.com/16-examples-of-the-madness-of-... https://www.science.org/content/article/origin-darwins-anxiety https://www.science.org/content/article/origin-darwins-anxie... Can't vouch for the accuracy of these descriptions but they don't suggest lack of neuroticism however brought on. Bodily dysfunction of whatever kind can be causative of course.