The odds are probably pretty low. The notification is hardware based; the manufacturer of a USB keyboard or mouse won’t matter. If you plug a hard drive into

The odds are probably pretty low. The notification is hardware based; the manufacturer of a USB keyboard or mouse won’t matter. If you plug a hard drive into the slow USB port, macOS will let you know. There have been thousands of different USB devices plugged into Macs since they adopted it in 1998; I doubt there’s going to be problems now.