In addition to native Django ORM calls (to whatever DB you're using), we've also used tastypie to surface MongoDB and SOLR search results to REST endpoints. Ed

In addition to native Django ORM calls (to whatever DB you're using), we've also used tastypie to surface MongoDB and SOLR search results to REST endpoints. Edit: I should mention that both were pretty painstaking the first go-around, but mostly due to my ignorance of the platform. I am thankful to know some more seasoned Tastypie users, so getting answers was pretty easy, and the Google Group is really good for Tastypie as well.