My understanding is that mitragynine is an mu-opioid partial agonist which limits its impact even in high doses. This is sort of in the same realm as Buprenorp

My understanding is that mitragynine is an mu-opioid partial agonist which limits its impact even in high doses. This is sort of in the same realm as Buprenorphine. Google claims it also doesn't recruit beta-arrestin but admittedly I'm out of my depth here. Presumably this proposed fentanyl replacement is still a full mu-opioid agonist for efficacy.