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> Coffee and tea contain bioactive ingredients like polyphenols and caffeine There are also studies that nicotine lowers dementia risk. Since caffeine and nic

> Coffee and tea contain bioactive ingredients like polyphenols and caffeine There are also studies that nicotine lowers dementia risk. Since caffeine and nicotine are both stimulants related to similar receptors, I wouldn't discount this other mechanism. I'm not saying anything about general healthiness of caffeine though.

nwah1 8mo ago
Would be interesting to know whether theacrine or paraxanthine can provide the same neuroprotection without as much downsides.
srean 8mo ago
> There are also studies that nicotine lowers dementia risk. It has been found to be negatively correlated with Parkinson's disease also. Does it not adversely affect cardiovascular health ? Even if it did, I would prefer keeping my mind and mobility.
- moritzwarhier 8mo ago
  Sorry it wasn't clear, I was not advocating for anything here, certainly not that people should smoke to prevent dementia. Large quantities of nicotine are poisonous (just like caffeine) and it is addictive (more so than caffeine). Regarding cardiovascular health, I'm not sure. As far as I know, nicotine itself is safe unless overdosed, but smoking and vaping of course is unhealthy. I like coffee, and drinking to much of it is also unhealthy. However, I love to remind myself of all the pop-sci articles saying that 2-3 cups are healthy when I'm making myself my 5th or 6th cup for the day.
  - srean 8mo ago
    Oh I did not think you were advocating anything. I was just thinking aloud. I used to drink lots of coffee earlier but now my caffeine metabolism seems to have ground to halt. Anything more than two mugs and night's sleep is history. Even that infrequent second mug pushes it a lot. In all fairness, my mug is around 2 to 3 espresso shots. Have to find myself some good local decaf. That's not easy in India.
    - moritzwarhier 8mo ago
      Oh I see, and tbh it's the same for me with sleep, I should be more discplined about caffeine given I have trouble sleeping anyway. Still often make the mistake of brewing a coffee in late afternoon because I love the ritual and it gets me off my desk. It also has replaced cigarette breaks for me. Drinking local coffee is admirable, but not an option in Germany :) I often buy "fair" brands in hope that does something but only when I can get it at OK prices... Since you mention decaf, mixing 50/50 decaf/regular is also a good option to reduce caffeine intake for me.

nwah1 8mo ago

Would be interesting to know whether theacrine or paraxanthine can provide the same neuroprotection without as much downsides.

srean 8mo ago

> There are also studies that nicotine lowers dementia risk. It has been found to be negatively correlated with Parkinson's disease also. Does it not adversely affect cardiovascular health ? Even if it did, I would prefer keeping my mind and mobility.

moritzwarhier 8mo ago
Sorry it wasn't clear, I was not advocating for anything here, certainly not that people should smoke to prevent dementia. Large quantities of nicotine are poisonous (just like caffeine) and it is addictive (more so than caffeine). Regarding cardiovascular health, I'm not sure. As far as I know, nicotine itself is safe unless overdosed, but smoking and vaping of course is unhealthy. I like coffee, and drinking to much of it is also unhealthy. However, I love to remind myself of all the pop-sci articles saying that 2-3 cups are healthy when I'm making myself my 5th or 6th cup for the day.
- srean 8mo ago
  Oh I did not think you were advocating anything. I was just thinking aloud. I used to drink lots of coffee earlier but now my caffeine metabolism seems to have ground to halt. Anything more than two mugs and night's sleep is history. Even that infrequent second mug pushes it a lot. In all fairness, my mug is around 2 to 3 espresso shots. Have to find myself some good local decaf. That's not easy in India.
  - moritzwarhier 8mo ago
    Oh I see, and tbh it's the same for me with sleep, I should be more discplined about caffeine given I have trouble sleeping anyway. Still often make the mistake of brewing a coffee in late afternoon because I love the ritual and it gets me off my desk. It also has replaced cigarette breaks for me. Drinking local coffee is admirable, but not an option in Germany :) I often buy "fair" brands in hope that does something but only when I can get it at OK prices... Since you mention decaf, mixing 50/50 decaf/regular is also a good option to reduce caffeine intake for me.