the gist is that virus has biological effects not dependant on replication. the whole virus approach is from a time when we barely understood what we were doin

the gist is that virus has biological effects not dependant on replication. the whole virus approach is from a time when we barely understood what we were doing, and were barely capable of doing it. topping it off j&j is using adenovirus vector technology, an approach plagued with problems from inception.