5 ms·

That was my thought as well. At least naively, it seems to follow that regularly donating blood might have health benefits. A typical donation is half a liter,

by delecti 8mo ago

That was my thought as well. At least naively, it seems to follow that regularly donating blood might have health benefits. A typical donation is half a liter, and a person has about 5 liters of blood, so donating should in theory remove about 10% of the crap you've got circulating, right? Edit: You can donate every 2 months, so donating as often as possible would roughly halve the crud every year (0.9^6 ~= 0.53, ignoring the natural increase over time).

johnisgood 8mo ago
Yeah, that is donating, now I wonder donating AND receiving (from a healthy individual). :D
- dylan604 8mo ago
  Why do you think Gavin Belson had a blood bag? This has been a trope for a while. They even had blood bags in the Fury Road movie, but that was more of a continuous supply than just trying to refresh like Gavin. I don't think using movie tropes in a discussion on vampires is out of line here
u1hcw9nx 8mo ago
I don't think it's very effective. It's your metabolism that produces that junk with increasing ratio of stuff that you need. If you just remove blood, the ratio of good stuff to bad stuff does not change. Same with kidney filtering if they can't recognize the difference. Blood transfusion from younger person gives you blood with better ratio.
- delecti 8mo ago
  The article includes a citation that explicitly states the opposite. Specifically citation 20 from the section "The Twist" (which is itself all about this idea): > [20] Mehdipour, M. et al. “Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.” Aging 12(10), 8790–8819, 2020. The UC Berkeley team found that diluting old blood plasma with saline and albumin produced rejuvenating effects comparable to young blood — suggesting the mechanism is removing pro-aging factors rather than adding youth factors. This was, at the time of publication, the strongest evidence that old blood is the problem, not that young blood is the solution. Maybe regularly donating blood would have more negative effects from losing good stuff than positive effects from losing bad stuff, or maybe not. There is evidence that it could be a net positive though. And even aside from the buildup of crud due to normal aging, environmental crud (nano/microplastics, PFAS, etc) is not produced by the body. It's still not totally settled science whether all of those things have negative effects, but regular blood donation would help clear it out, at least a little.
  - FarmerPotato 8mo ago
    I was waiting for someone to consider the idea of synthetic dilutants. But a further horror is: you’re dumping your crud on the person getting your transfusion? I guess it’s better than dying in ER.
    - delecti 8mo ago
      Yeah, unless your blood is significantly more cruddy than average, the recipient shouldn't really care that you had ulterior motives behind donating.
  - u1hcw9nx 8mo ago
    The article confirms what I just wrote. Albumins are proteins. If you add more albumins, the ratio changes. dilution = change of ratio. Just giving blood is not dilution.
RajT88 8mo ago
2 months for whole blood IIRC. You can do every 2 weeks for platelets, but I am not sure if that removes the crud or not. There's other donations with varying frequency (red, plasma, etc.).
- maleldil 8mo ago
  I'm assuming this is in the US? I'm curious why it's 2 months there but 3 or 4 (men/women) in the UK.
  - delecti 8mo ago
    More vampires further north, so most people have less extra blood? But more seriously, it seems like 2 months is enough for most people, but not everyone. So it just comes down to whether you want to turn some people away at donation time because their iron is too low, or make everyone wait a bit longer between regular donations.
  - RajT88 8mo ago
    I don't donate whole blood too often (they usually want me for platelets every 2 weeks if they can get it). https://versiti.org/ways-to-give/about-blood-donation/blood-donation-faqs https://versiti.org/ways-to-give/about-blood-donation/blood-... 56 days or 8 weeks for whole blood. It doesn't say why.
toast0 8mo ago
> it seems to follow that regularly donating blood might have health benefits It's pretty effective if you have excess iron (hemochromatosis) and your local vampires accept your donation; some don't because a donation where you get a significant benefit isn't a donation for the sole reason of helping others (and a free cookie). In that case, traditional bloodletting may be required.
robocat 8mo ago
In New Zealand, you are stopped at 75 (or 81 if given an exemption) assuming you started donating before 71. You can't start donating blood after 71. From age section: https://www.nzblood.co.nz/become-a-donor/am-i-eligible/detailed-eligibility-criteria https://www.nzblood.co.nz/become-a-donor/am-i-eligible/detai...

by delecti 8mo ago

johnisgood 8mo ago

Yeah, that is donating, now I wonder donating AND receiving (from a healthy individual). :D

dylan604 8mo ago
Why do you think Gavin Belson had a blood bag? This has been a trope for a while. They even had blood bags in the Fury Road movie, but that was more of a continuous supply than just trying to refresh like Gavin. I don't think using movie tropes in a discussion on vampires is out of line here

u1hcw9nx 8mo ago

I don't think it's very effective. It's your metabolism that produces that junk with increasing ratio of stuff that you need. If you just remove blood, the ratio of good stuff to bad stuff does not change. Same with kidney filtering if they can't recognize the difference. Blood transfusion from younger person gives you blood with better ratio.

delecti 8mo ago
The article includes a citation that explicitly states the opposite. Specifically citation 20 from the section "The Twist" (which is itself all about this idea): > [20] Mehdipour, M. et al. “Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.” Aging 12(10), 8790–8819, 2020. The UC Berkeley team found that diluting old blood plasma with saline and albumin produced rejuvenating effects comparable to young blood — suggesting the mechanism is removing pro-aging factors rather than adding youth factors. This was, at the time of publication, the strongest evidence that old blood is the problem, not that young blood is the solution. Maybe regularly donating blood would have more negative effects from losing good stuff than positive effects from losing bad stuff, or maybe not. There is evidence that it could be a net positive though. And even aside from the buildup of crud due to normal aging, environmental crud (nano/microplastics, PFAS, etc) is not produced by the body. It's still not totally settled science whether all of those things have negative effects, but regular blood donation would help clear it out, at least a little.
- FarmerPotato 8mo ago
  I was waiting for someone to consider the idea of synthetic dilutants. But a further horror is: you’re dumping your crud on the person getting your transfusion? I guess it’s better than dying in ER.
  - delecti 8mo ago
    Yeah, unless your blood is significantly more cruddy than average, the recipient shouldn't really care that you had ulterior motives behind donating.
- u1hcw9nx 8mo ago
  The article confirms what I just wrote. Albumins are proteins. If you add more albumins, the ratio changes. dilution = change of ratio. Just giving blood is not dilution.

RajT88 8mo ago

2 months for whole blood IIRC. You can do every 2 weeks for platelets, but I am not sure if that removes the crud or not. There's other donations with varying frequency (red, plasma, etc.).

maleldil 8mo ago
I'm assuming this is in the US? I'm curious why it's 2 months there but 3 or 4 (men/women) in the UK.
- delecti 8mo ago
  More vampires further north, so most people have less extra blood? But more seriously, it seems like 2 months is enough for most people, but not everyone. So it just comes down to whether you want to turn some people away at donation time because their iron is too low, or make everyone wait a bit longer between regular donations.
- RajT88 8mo ago
  I don't donate whole blood too often (they usually want me for platelets every 2 weeks if they can get it). https://versiti.org/ways-to-give/about-blood-donation/blood-donation-faqs https://versiti.org/ways-to-give/about-blood-donation/blood-... 56 days or 8 weeks for whole blood. It doesn't say why.

toast0 8mo ago

> it seems to follow that regularly donating blood might have health benefits It's pretty effective if you have excess iron (hemochromatosis) and your local vampires accept your donation; some don't because a donation where you get a significant benefit isn't a donation for the sole reason of helping others (and a free cookie). In that case, traditional bloodletting may be required.

robocat 8mo ago

In New Zealand, you are stopped at 75 (or 81 if given an exemption) assuming you started donating before 71. You can't start donating blood after 71. From age section: https://www.nzblood.co.nz/become-a-donor/am-i-eligible/detailed-eligibility-criteria https://www.nzblood.co.nz/become-a-donor/am-i-eligible/detai...