Most of the results here are in mice, but they apparently did a small pilot study in humans: https://www.chictr.org.cn/showprojEN.html?proj=176336 https://www.

Most of the results here are in mice, but they apparently did a small pilot study in humans: https://www.chictr.org.cn/showprojEN.html?proj=176336 https://www.chictr.org.cn/showprojEN.html?proj=176336 To the extent that there are results, they're paywalled. But, oddly, the entire article appears to be posted in the supplemental information section: https://www.cell.com/cms/10.1016/j.cmet.2026.01.008/attachment/f949ab6c-cd86-4189-b114-ae62328a246c/mmc4.pdf https://www.cell.com/cms/10.1016/j.cmet.2026.01.008/attachme... From Figure 1, the effect size in mice was fairly large. Pages 9 and 10 give a very brief description of the human trial. It looks like they did not make any effort to disentangle effects due to weight loss from effects independent of weight loss in humans. The humans in the study group had a 17% increase in knee cartilage thickness, and the dose used was (see page e3): "Participants receiving SG treatment initiated with a dose of 0.25 mg in the first week, and increased the dose in a stepwise manner each subsequent week until reaching the target dose of 0.5 mg/week (incremental steps of 0.125 mg)." AIUI this matches the current recommended starting dosage for diabetes and is considerably lower than the dosages used for weight loss.