4 ms·

If it can somehow restore spinal disc function, I'm gonna start snorting the stuff.

nwienert 8mo ago
It's a miracle drug for reducing immune overreach, like better than anything we know of. This is also completely outside of the weight loss effects. My lower back is improved by it. It'll come to be known that these drugs are far better for people in a broad way than even thought today. They seem to have at least 4 effects that individually should be considered a "miracle."
- quantumwoke 8mo ago
  Can you give some examples of immune overreach that are improved?
  - wincy 8mo ago
    My wife has had an autoimmune disease that’s caused inflammation for years. Absolutely terrible back pain. She had to rent a motorized scooter when we went to Disney World, and could barely walk a few hundred feet before having to stop and rest for years. Last year she started Zepbound (tirzepatide) and the inflammation went away, we went to Disney World again and she walked happily all day. Absolutely life changing. She didn’t even lose much weight and this was at the lowest dose.
    - nwienert 8mo ago
      Tirzepatide specifically seems especially beneficial, likewise here. Years of slowly increasing symptoms since I was young, lifelong annoying issues, basically all gone on it. And also not overweight at all, I take below lowest dose and skip most weeks now that it's under control.
JMKH42 8mo ago
I have a bad disc, and while its still bad, a couple weeks of freestyle swimming workouts makes it not hurt for a year or two and lets me mountain bike comfortably again. Something to try if the usual stuff doesn't work, as it tends not to! This was the disc between lumbar and sacrum. 1,000 ways to have a bad disc so results will vary a lot!
schnebbau 8mo ago
I had a bulging lumbar disc - pure agony for 18 months. I had become used to carrying a lumbar pillow around with me everywhere I went. I couldn't lean forward for more than about 30 seconds without it being unbearable. Then someone suggested I try dead hangs, stretching my hamstrings, and really cranking the McKenzie stretch. I'm not sure which one made the difference (all 3?), but pain was gone in 2 weeks. Maybe it will help, maybe it won't. But since someone took a flyer telling me, I always share this with others in the small chance it helps them.
- properbrew 8mo ago
  Do you have any links for how you did these stretches? I know someone that could do with trying this.
  - schnebbau 8mo ago
    For hamstring stretch I find using a back extension station works well, doing one leg at a time (https://m.media-amazon.com/images/I/61TQEGNUgQL._AC_UF894,1000_QL80_.jpg https://m.media-amazon.com/images/I/61TQEGNUgQL._AC_UF894,10...). Let gravity pull your torso down, which will stretch your hamstring. If that's not possible, using the corner of a wall works too (https://i.ytimg.com/vi/2U4ChnuL3JM/maxresdefault.jpg https://i.ytimg.com/vi/2U4ChnuL3JM/maxresdefault.jpg) For the McKenzie stretch (https://images.squarespace-cdn.com/content/v1/5e556aadfe97d3364e789f90/1593630609498-PNFLELOEW2WCU1N3QD65/mckenzie.jpg https://images.squarespace-cdn.com/content/v1/5e556aadfe97d3...), instead of just holding the stretch, do reps between laying flat and then going into the stretch. At the end of your final rep (I would do 8), rotate side to side gently when arched. Dead hangs: hang from a bar for 30 seconds, completely relaxed. Then 1 minute of rest. Repeat 3 times. This decompresses your spine.
    - properbrew 8mo ago
      Thanks for the reply, will pass this info on.
- mrmuagi 8mo ago
  McKenzie stretched helped me rehab a pulled muscle in my lower back (originally thought it was a disc). Deadlifts also helped strengthen lower back muscles. Tight hamstrings from sitting on the computer all the time also didn't help. I'll try dead hangs.
boelboel 8mo ago
SW033291 or MF-300 might be interesting to look out for with spinal function. https://www.sciencedaily.com/releases/2026/01/260120000333.htm https://www.sciencedaily.com/releases/2026/01/260120000333.h...
malfist 8mo ago
I know you're getting a lot of "this worked for me" responses and I wanted to throw one more in. I used to have lower back problems all the time, but after following a strength training program for the olympic lifts with a personal trainer, generally the only time I have lower back pain now is if I've gone too hard to deadlifts or rows, not from general day to day things.

It's a miracle drug for reducing immune overreach, like better than anything we know of. This is also completely outside of the weight loss effects. My lower back is improved by it. It'll come to be known that these drugs are far better for people in a broad way than even thought today. They seem to have at least 4 effects that individually should be considered a "miracle."

quantumwoke 8mo ago
Can you give some examples of immune overreach that are improved?
- wincy 8mo ago
  My wife has had an autoimmune disease that’s caused inflammation for years. Absolutely terrible back pain. She had to rent a motorized scooter when we went to Disney World, and could barely walk a few hundred feet before having to stop and rest for years. Last year she started Zepbound (tirzepatide) and the inflammation went away, we went to Disney World again and she walked happily all day. Absolutely life changing. She didn’t even lose much weight and this was at the lowest dose.
  - nwienert 8mo ago
    Tirzepatide specifically seems especially beneficial, likewise here. Years of slowly increasing symptoms since I was young, lifelong annoying issues, basically all gone on it. And also not overweight at all, I take below lowest dose and skip most weeks now that it's under control.

JMKH42 8mo ago

I have a bad disc, and while its still bad, a couple weeks of freestyle swimming workouts makes it not hurt for a year or two and lets me mountain bike comfortably again. Something to try if the usual stuff doesn't work, as it tends not to! This was the disc between lumbar and sacrum. 1,000 ways to have a bad disc so results will vary a lot!

schnebbau 8mo ago

I had a bulging lumbar disc - pure agony for 18 months. I had become used to carrying a lumbar pillow around with me everywhere I went. I couldn't lean forward for more than about 30 seconds without it being unbearable. Then someone suggested I try dead hangs, stretching my hamstrings, and really cranking the McKenzie stretch. I'm not sure which one made the difference (all 3?), but pain was gone in 2 weeks. Maybe it will help, maybe it won't. But since someone took a flyer telling me, I always share this with others in the small chance it helps them.

properbrew 8mo ago
Do you have any links for how you did these stretches? I know someone that could do with trying this.
- schnebbau 8mo ago
  For hamstring stretch I find using a back extension station works well, doing one leg at a time (https://m.media-amazon.com/images/I/61TQEGNUgQL._AC_UF894,1000_QL80_.jpg https://m.media-amazon.com/images/I/61TQEGNUgQL._AC_UF894,10...). Let gravity pull your torso down, which will stretch your hamstring. If that's not possible, using the corner of a wall works too (https://i.ytimg.com/vi/2U4ChnuL3JM/maxresdefault.jpg https://i.ytimg.com/vi/2U4ChnuL3JM/maxresdefault.jpg) For the McKenzie stretch (https://images.squarespace-cdn.com/content/v1/5e556aadfe97d3364e789f90/1593630609498-PNFLELOEW2WCU1N3QD65/mckenzie.jpg https://images.squarespace-cdn.com/content/v1/5e556aadfe97d3...), instead of just holding the stretch, do reps between laying flat and then going into the stretch. At the end of your final rep (I would do 8), rotate side to side gently when arched. Dead hangs: hang from a bar for 30 seconds, completely relaxed. Then 1 minute of rest. Repeat 3 times. This decompresses your spine.
  - properbrew 8mo ago
    Thanks for the reply, will pass this info on.
mrmuagi 8mo ago
McKenzie stretched helped me rehab a pulled muscle in my lower back (originally thought it was a disc). Deadlifts also helped strengthen lower back muscles. Tight hamstrings from sitting on the computer all the time also didn't help. I'll try dead hangs.

boelboel 8mo ago

SW033291 or MF-300 might be interesting to look out for with spinal function. https://www.sciencedaily.com/releases/2026/01/260120000333.htm https://www.sciencedaily.com/releases/2026/01/260120000333.h...

malfist 8mo ago

I know you're getting a lot of "this worked for me" responses and I wanted to throw one more in. I used to have lower back problems all the time, but after following a strength training program for the olympic lifts with a personal trainer, generally the only time I have lower back pain now is if I've gone too hard to deadlifts or rows, not from general day to day things.