2 ms·

have u ever tried niacin?

• Noaidi 8mo ago
  Yes. Made me manic. You know we make niacin in our own bodies, from tryptophan, down the kynurenine pathway. Sine many of the enzymes that are in this pathway need B6 and B2, being low in these may lower endogenous niacin in the body. https://www.researchgate.net/publication/353319033/figure/fig1/AS:1046791600472088@1626585974241/Schematic-overview-of-the-kynurenine-pathway-The-first-and-rate-limiting-step-is.png https://www.researchgate.net/publication/353319033/figure/fi... Many people I know, when tested, were low in B6. That is more important to me than niacin.
  • ulnarkressty 8mo ago
    For others who want to try this, taking too much B6 is associated with nerve damage - https://en.wikipedia.org/wiki/Megavitamin-B6_syndrome https://en.wikipedia.org/wiki/Megavitamin-B6_syndrome
    • lII1lIlI11ll 8mo ago
      From your link: "The common supplemental form of vitamin B6, pyridoxine, is similar to pyridine, which can be neurotoxic." Vitamin B6 in p5p form is cheap and widely available alternative.