4 ms·

Bit off-topic, but melatonin taken at right doses appears to work very well. (commonly prescribed doses are 10-30x too much and likely cause tolerance). See the

Bit off-topic, but melatonin taken at right doses appears to work very well. (commonly prescribed doses are 10-30x too much and likely cause tolerance). See the post https://slatestarcodex.com/2018/07/10/melatonin-much-more-than-you-wanted-to-know/ https://slatestarcodex.com/2018/07/10/melatonin-much-more-th...

corv 8mo ago
I’ve heard this before that common doses are unnecessarily high but why is that? Patents?
- zemvpferreira 8mo ago
  Rather, lack of. Melatonin is over-the-counter, generic, badly understood by the people taking it and dosed according to personal preference which means marketing it is all abouy big numbers. Bigger number on package = more sales.
- quietsegfault 8mo ago
  > why is that Why buy 1mg pill when you can buy 100mg pill?
  - temp0826 8mo ago
    Even funnier is that often 0.25mg or 0.5mg is closer to the correct dose, and those sizes tend to be hard to find. There actually is a condition that calls for extremely high (100mg+ doses), but it is a very rare thing, no one should ever consider that much without instruction from a doctor. But you'll find it right next to the normal <=5mg doses without any explanation.
    - calfuris 8mo ago
      The Natrol liquid isn't usually too hard to track down. They advertise it as 1 mg or 2.5 mg, but it's the same stuff, the bottle just direct you to take 4 or 10 mL respectively.
      - Projectiboga 8mo ago
        So 1ml (20 drops) would yeild an average dose of .25mg in that form.
- kstrauser 8mo ago
  They’re considered dietary supplements and not medicine, so they’re not meaningfully regulated in the way meds are.
- Projectiboga 8mo ago
  The help aiding sleep is only one function for melatonin. The reason for higher suggested doses is due to its anti-oxident function. From personal experience melatonin needs to be paired with vitamin e to really clear out over night. I take vitamin e as I get into bed right before I take a melatonin sublingual. Another benefit of melatonin is that it upregulates our insulin receptors.

corv 8mo ago

I’ve heard this before that common doses are unnecessarily high but why is that? Patents?

zemvpferreira 8mo ago
Rather, lack of. Melatonin is over-the-counter, generic, badly understood by the people taking it and dosed according to personal preference which means marketing it is all abouy big numbers. Bigger number on package = more sales.
quietsegfault 8mo ago
> why is that Why buy 1mg pill when you can buy 100mg pill?
- temp0826 8mo ago
  Even funnier is that often 0.25mg or 0.5mg is closer to the correct dose, and those sizes tend to be hard to find. There actually is a condition that calls for extremely high (100mg+ doses), but it is a very rare thing, no one should ever consider that much without instruction from a doctor. But you'll find it right next to the normal <=5mg doses without any explanation.
  - calfuris 8mo ago
    The Natrol liquid isn't usually too hard to track down. They advertise it as 1 mg or 2.5 mg, but it's the same stuff, the bottle just direct you to take 4 or 10 mL respectively.
    - Projectiboga 8mo ago
      So 1ml (20 drops) would yeild an average dose of .25mg in that form.
kstrauser 8mo ago
They’re considered dietary supplements and not medicine, so they’re not meaningfully regulated in the way meds are.
Projectiboga 8mo ago
The help aiding sleep is only one function for melatonin. The reason for higher suggested doses is due to its anti-oxident function. From personal experience melatonin needs to be paired with vitamin e to really clear out over night. I take vitamin e as I get into bed right before I take a melatonin sublingual. Another benefit of melatonin is that it upregulates our insulin receptors.