3 ms·

Cholesterol levels cut in half with one-time gene editing drug in trial

20 points by brandonb 9mo ago

bediger4000 9mo ago
[flagged]
- johng 9mo ago
  I think it's a bit more nuanced than that. Especially when the lies were so obvious. You can't get COVID if you get the vaccine (A lie), You can't spread COVID if you get the vaccine (A lie). If they would have been honest from the start -- that you are less likely to need to take up limited hospital beds if you got the vaccine, I think people would have responded better. Then there were the obviously stupid mask rules.... wear a mask, stand in lane, separate... but as soon as you sit down at a table, you can take off the mask and now all of the sudden the disease magically can't spread. No gathering outside, no going to church, even outside if you provide plenty of space or we will arrest you. However, riots lining up body to body for the cause of the week is perfectly fine without masks. The hypocrisy of the whole situation was obvious and undeniable. I'm sure you are partly true with some of the Trump hard core lover people.... but there are a LOT of silent majority in the middle that don't like Trump but dislike the lies and hypocricy much much more.
  - appplication 9mo ago
    > You can't get COVID if you get the vaccine (A lie), You can't spread COVID if you get the vaccine (A lie). I don’t recall this. My memory was that the messaging was primarily around reduced risk of serious illness /death and reduced risk of transmission. I do recall the CDC or whoever in the early days saying not to wear masks, which felt like an obvious lie, I presumed at the time to protect supplies for medical professionals. I also recall it was a few years before they acknowledged it was airborne, despite having sufficient evidence it may be quite some time (and previously messaging was that it was affirmatively not airborne). The pandemic sucked but the politics around it were just so gross and disheartening. Anyhow, this is all way off topic for the original article.
  - bediger4000 9mo ago
    Nobody said you couldn't get COVID if you got vaccinated. I lived through it, I paid attention, you can't lie to me about that. There was some talk about 90+% effective, that means it's good, but not smallpox vaccine good. Nobody, but nobody said you couldn't spread it if you were vaccinated.
nuc1e0n 9mo ago
This is not an acceptable use of gene editing IMHO. Cholesterol can be managed by diet. High levels of Cholesterol are down to choices made, not some inherited disease that patients couldn't avoid from when they were born.
- kelseyfrog 9mo ago
  Same thing with T2D. If your blood sugar is disregulated due to insulin sensitivity disorder, you should simply die.
  - wpm 9mo ago
    And depression as well, you gotta just buck up and smile and try real hard to not jump off of a bridge.
    - kelseyfrog 9mo ago
      Right, all mental health problems are a choice (or a call for attention).
  - nuc1e0n 9mo ago
    I wouldn't go that far. Other, less invasive treatments should still be available IMHO, but there should remain an element of personal accountability. Gene editing is a very powerful tool, and messing with complex systems in powerful ways that we don't fully understand could be a recipe for many troubles down the line. I think the use of gene editing should be very surgically applied to obviously detrimental mutations, not for some scatter gun like approach. What if the body raising cholesterol levels serves some purpose we aren't yet aware of? I've heard there's some evidence that medication to reduce blood pressure has a potential link to the onset of Parkinson's disease. Maybe messing with blood pressure in that way without addressing underlying causes has been a mistake, and messing with cholesterol levels without addressing underlying causes could also be.
    - gizmo686 9mo ago
stefantalpalaru 9mo ago
[dead]
Eliza113 9mo ago
I was diagnosed with Parkinson’s disease four years ago. For over two years, I relied on Levodopa and several other medications, but unfortunately, the symptoms kept getting worse. The tremors became more noticeable, and my balance and mobility started to decline quickly. Last year, out of desperation and hope, I decided to try a herbal treatment program from NaturePath Herbal Clinic. Honestly, I was skeptical at first, but within a few months of starting the treatment, I began to notice real changes. My movements became smoother, the tremors subsided, and I felt steadier on my feet. Incredibly, I also regained much of my energy and confidence. It’s been a life-changing experience I feel more like myself again, better than I’ve felt in years.If you or a loved one is struggling with Parkinson’s disease, I truly recommend looking into their natural approach. You can visit their website at www.naturepathherbalclinic.com info@ naturepathherbalclinic .com

20 points by brandonb 9mo ago

bediger4000 9mo ago

[flagged]

johng 9mo ago
I think it's a bit more nuanced than that. Especially when the lies were so obvious. You can't get COVID if you get the vaccine (A lie), You can't spread COVID if you get the vaccine (A lie). If they would have been honest from the start -- that you are less likely to need to take up limited hospital beds if you got the vaccine, I think people would have responded better. Then there were the obviously stupid mask rules.... wear a mask, stand in lane, separate... but as soon as you sit down at a table, you can take off the mask and now all of the sudden the disease magically can't spread. No gathering outside, no going to church, even outside if you provide plenty of space or we will arrest you. However, riots lining up body to body for the cause of the week is perfectly fine without masks. The hypocrisy of the whole situation was obvious and undeniable. I'm sure you are partly true with some of the Trump hard core lover people.... but there are a LOT of silent majority in the middle that don't like Trump but dislike the lies and hypocricy much much more.
- appplication 9mo ago
  > You can't get COVID if you get the vaccine (A lie), You can't spread COVID if you get the vaccine (A lie). I don’t recall this. My memory was that the messaging was primarily around reduced risk of serious illness /death and reduced risk of transmission. I do recall the CDC or whoever in the early days saying not to wear masks, which felt like an obvious lie, I presumed at the time to protect supplies for medical professionals. I also recall it was a few years before they acknowledged it was airborne, despite having sufficient evidence it may be quite some time (and previously messaging was that it was affirmatively not airborne). The pandemic sucked but the politics around it were just so gross and disheartening. Anyhow, this is all way off topic for the original article.
- bediger4000 9mo ago
  Nobody said you couldn't get COVID if you got vaccinated. I lived through it, I paid attention, you can't lie to me about that. There was some talk about 90+% effective, that means it's good, but not smallpox vaccine good. Nobody, but nobody said you couldn't spread it if you were vaccinated.

nuc1e0n 9mo ago

This is not an acceptable use of gene editing IMHO. Cholesterol can be managed by diet. High levels of Cholesterol are down to choices made, not some inherited disease that patients couldn't avoid from when they were born.

kelseyfrog 9mo ago
Same thing with T2D. If your blood sugar is disregulated due to insulin sensitivity disorder, you should simply die.
- wpm 9mo ago
  And depression as well, you gotta just buck up and smile and try real hard to not jump off of a bridge.
  - kelseyfrog 9mo ago
    Right, all mental health problems are a choice (or a call for attention).
- nuc1e0n 9mo ago
  I wouldn't go that far. Other, less invasive treatments should still be available IMHO, but there should remain an element of personal accountability. Gene editing is a very powerful tool, and messing with complex systems in powerful ways that we don't fully understand could be a recipe for many troubles down the line. I think the use of gene editing should be very surgically applied to obviously detrimental mutations, not for some scatter gun like approach. What if the body raising cholesterol levels serves some purpose we aren't yet aware of? I've heard there's some evidence that medication to reduce blood pressure has a potential link to the onset of Parkinson's disease. Maybe messing with blood pressure in that way without addressing underlying causes has been a mistake, and messing with cholesterol levels without addressing underlying causes could also be.
  - gizmo686 9mo ago

stefantalpalaru 9mo ago

[dead]

Eliza113 9mo ago

I was diagnosed with Parkinson’s disease four years ago. For over two years, I relied on Levodopa and several other medications, but unfortunately, the symptoms kept getting worse. The tremors became more noticeable, and my balance and mobility started to decline quickly. Last year, out of desperation and hope, I decided to try a herbal treatment program from NaturePath Herbal Clinic. Honestly, I was skeptical at first, but within a few months of starting the treatment, I began to notice real changes. My movements became smoother, the tremors subsided, and I felt steadier on my feet. Incredibly, I also regained much of my energy and confidence. It’s been a life-changing experience I feel more like myself again, better than I’ve felt in years.If you or a loved one is struggling with Parkinson’s disease, I truly recommend looking into their natural approach. You can visit their website at www.naturepathherbalclinic.com info@ naturepathherbalclinic .com