7 ms·
Scientists find a way to regrow cartilage in mice and human tissue samples
- CromDonkey 9mo agoMy god how do I volunteer?
- jleyank 9mo agoAs long as regrowth can be controlled. Otherwise we call it cancer. Would be amazing to get a treatment for osteoarthritis.
- deburo 9mo agoYou should check out Michael Levin. Cancerous cells do not grow organ-like structures. Normal cells communicate with other cells as a network to control growth.
- da02 9mo agoI had good results with hyaluronic acid for knee osteoarthritis. Sometimes they sell it as Type II Collagen. "Source Naturals Hyaluronic Joint Complex" was the best for my relatives/friends' knee problems. I take it a few times a month (with resveratrol) for smooth skin. I have been taking it since 2008 without any negative result.
- kenjackson 9mo agoHow does Type II Collagen work for patella tendonitis? I have jumpers knee (chronic) and would love to find something that helps -- even a little.
- da02 9mo agoSeems like it should work. I do not have experience with that condition. A quick search online (patella tendonitis hyaluronic acid) yielded this study: https://pubmed.ncbi.nlm.nih.gov/22526713/ https://pubmed.ncbi.nlm.nih.gov/22526713/ So they are using hyaluronic acid injections for patella tendonitis. Taking hyaluronic acid orally would probably take longer for effects compared to injections. Most people would prefer the injections because they feel safer for a doctor to do all the work. I prefer the tablets. If you have the money, I guess go for the injections. I would use the H.A. tablets. (With a tall glass of water, and do not take at the same time as blood-thinning medication, like pain killers or drugs.)
- blakesterz 9mo agoOf course, why are the good ones always in mice? A study led by Stanford Medicine researchers has found that an injection blocking a protein linked to aging can reverse the natural loss of knee cartilage in older mice.
- agumonkey 9mo agoI guess we should pay scientist to look into the human-to-mice transformation problem
- random3 9mo agoThis :))) or the other way around
- LoveMortuus 9mo agoI would love that, as long as the lifespan didn't change. If everyone turned into mice we'd have a lot more space for other stuff, we'd need less food, less resources in general, since we'd be physically smaller, this thought is one of the reasons I like the movie arthur and the minimoys, where the main character gets shrunk to like 2mm in size!
- seydor 9mo agoWe live in the Matrix, and Mice are the overlords.
- IAmBroom 9mo ago"A chemical is something that causes cancer in lab mice." By analogy, "A drug is something that cures cancer in lab mice."
- tima101 9mo agohttps://www.science.org/doi/10.1126/science.adx6649 https://www.science.org/doi/10.1126/science.adx6649 A small molecule inhibitor of 15-hydroxy prostaglandin dehydrogenase causes cartilage regeneration. I hope they fast-track it to human trials.
- fraserharris 9mo ago"Phase 1 clinical trials of a 15-PGDH inhibitor for muscle weakness have shown that it is safe and active in healthy volunteers. Our hope is that a similar trial will be launched soon to test its effect in cartilage regeneration" - Helen Blau, Baxter Laboratory for Stem Cell Biology & the Donald E. and Delia B. Baxter Foundation Professorship
- mobilejdral 9mo agoERa activation promotes PGE2 resulting in decreased 15-PGDH. So this is one of those standard poor estrogen signaling downstream things and simply improving the estrogen signaling and you get improved cartilage. Anyone can do this today along with getting all of the other positive effects. Those with EDS who have say variants on their TNXA/B have poor production ability to start and so we do everything we can to improve their cartilage production as they can only make so much which include doing stuff like this.
- shermantanktop 9mo agoEDS and arthritis go together so I wonder if we could see secondary effects on other EDS symptoms like subluxation or GI issues?
- amluto 9mo ago> Anyone can do this today Please explain
- RealityVoid 9mo agoYes, I deff want this explained, since I'm missing about half of my meniscus.
- llmslave 9mo agobasically every growth process in the body can be induced by chemicals. and so now people are starting to take some of these chemicals. we will see how it turns out
- arjie 9mo agoFusion Power Cartilage Regrowth Room Temperature Semiconductors Quantum Computing def generate(topic, year): return f"Scientists have made a major breakthrough in {topic}" The only subjects that are more Year Of The Linux Desktop than Linux itself.
- legohead 9mo agoBattery tech
- KellyCriterion 9mo agoBlockchain & DeFi! Bingo! :-D
- bramhaag 9mo agoDon't forget about Alzheimer's disease
- razingeden 9mo agoI’m familiar with Helen Blau, her team is into everything: telomeres and aging, reversing cardiomyopathy, HIV, that team is really hardcore into prolonging and improving lives and wellness. Heard. But if even one of their interests panned out it would be paradigm changing for millions and they’re doing it to save your lives not get a updoot on hacker news. They’re all pretty anonymous and understated Imo but i am a great fan and i would love for it to be the “year of” anything they’re studying. I listed a few and I’m sure there’s dozens I’m unaware of. I’ve been thinking that this stuff is all more closely related than we think and that as they go down one of these paths they’re finding all this other stuff along the way, it’s genuinely fascinating. Heart disease and failure is one of the biggest ways we meet our ends right now. There’s so much interplay between aging processes, ceasing t-cell production, shortening telomeres , that ties in together with this and im glad they see a bigger picture than me having another 20 years , too winded to stand up and piss or strapped to a bed hooked to tubes and groaning!
- carlmr 9mo ago>Year Of The Linux Desktop After Win11 Microsoft really did all they could to get us there this year.
- deleted 9mo ago[deleted]
- inglor_cz 9mo agoThe discovery of gerozymes is interesting. Maybe aging is pre-programmed after all, to make space for new generations.
- clickety_clack 9mo agoWould this work for rheumatoid arthritis? I don’t know anything about it myself so it could be a completely different thing, but someone I know has it and it is awful. Would be great to see a treatment coming through.
- 331c8c71 9mo agora is autoimmune
- surfsvammel 9mo agoMy dream is to be able to run again. Please. Let me run a 10k at least once more in my life. To feel that stillness and freedom and calm that sets in when the brain start going to hibernation after about 7km. That would be quiet something to feel that again.
- pegasus 9mo agoHope you see your dream realized. But know that that stillness is achievable through other activities as well. Most directly and deeply, through a meditation practice which is geared towards reaching those deep meditation states (called Jhanas in the Pali canon). My favorite guide on that particular path is Leigh Brasington.
- steve_adams_86 9mo agoCan you swim? This is the only thing besides running that gets me there.
- cromulent 9mo agoA Concept 2 rowing machine can also do this (in my experience). No impact, similar to swimming.
- munificent 9mo agoI broke my ankle nearly two years ago. I've had three surgeries already and will be getting a total ankle replacement in about a month. Even with that, I will never run again. Sometimes in a dream, I'll start running. I'll notice how magically effortless it feels. How wonderful to be able to run again. Then a little voice in the back of my head reminds me that this can't be real. It wakes me up every time. It was a rough day when I opened Strava to log one of my physical therapy walks and realized that if I scroll down a bit, I can find a record of the longest run I will ever do. I'm mostly at peace with it now. I'm grateful that at least I was into running for a while before I lost it, so at least I don't regret never having done it. And I never really enjoyed it then anyway. I just did it for health reasons and the sense of accomplishment. I'm sorry for your suffering. I know what this longing feels like.
- levl289 9mo agoI’ve had my shoulders “cleaned up” arthroscopically, and the pain is still a major preventer of movement. I would love to stay on the mats longer with something that doesn’t harken to medieval times. So excited at this prospect.
- glitchc 9mo agoIt does get better with physio and exercise. Took me twenty years to recover full (100%) pain-free mobility. It still occasionally finds itself in an uncomfortable spot that can be self-freed, but it can now hold muscle tone across the fascia.
- shermantanktop 9mo agoHN posts about mouse studies always trigger a bunch of skepticism. I’m a layperson so it’s hard to separate the informed comments from me-too contrarians. Are there areas of medicine where mouse models have a much higher or lower success rate in human trials?
- okaram 9mo agoThere's two issues, success rate (about 5%) and time ... even if it is successful in humans, it will be 5 to 10 years before it's available (and 20-30 before it's affordable) This is not being a contrarian, but a realist.
- d3rockk 9mo agoTo be fair, this same realist perspective seems to suggest humans would not have been capable of developing a COVID vaccine for 5 to 10 years; yet, they identified the virus and authorized vaccine use within eight months.
- mrexroad 9mo agoNot to diminish the accomplishment of rolling out the Covid vaccine in such a rapid timeframe, but… there was something like 40+ years of research into creating mRNA vaccines that laid the ground work.
- darth_avocado 9mo ago> and 20-30 before it's affordable Not if pharma execs and shareholders have anything to say about that
- samus 9mo agoIt has also been tested in cartilage samples from knee replacement surgeries.
- chkaloon 9mo agoYears and years away unfortunately. Many trials and chances for failure on the human side. It's discouraging to see these on HN and then realize that most never go anywhere, or are so far out you may not see it in your lifetime. Maybe we should flag anything not already in a phase 3 trial :)
- capitainenemo 9mo agoWell, the article notes that it seemed effective on human tissue samples. The researchers also tested cartilage taken from patients undergoing total knee replacement for osteoarthritis. After one week of treatment with the 15-PGDH inhibitor, the tissue showed fewer 15-PGDH-producing chondrocytes, reduced expression of cartilage degradation and fibrocartilage genes, and early signs of articular cartilage regeneration. So, IMO that shows hope for once it goes to trials.
- 1970-01-01 9mo ago>Human cartilage samples taken from knee replacement surgeries also responded positively. These samples included both the supportive extracellular matrix of the joint and cartilage-producing chondrocyte cells. When treated, the tissue began forming new, functional cartilage. Once again, not in humans, in mice. We don't know if the same result happens in humans. At all. We need to proceed to clinical trials to determine if a result is indeed positive.
- GuestFAUniverse 9mo agohttps://www.sciencedirect.com/science/article/abs/pii/S0163725825000385 https://www.sciencedirect.com/science/article/abs/pii/S01637... Reduce arthritis, get cancer?
- observationist 9mo agoWith all the mouse research, a lab should compile the top 300 interventions, lifestyles, regimens, etc, and apply it to a generation of mice. Give them all the best of the best gene edits, diets, environments, drug regimens, therapies, exercise, enrichment, and everything else. Get one or two broods of pups each year and breed them for healthspan and well-being, and each year, incorporate the latest and greatest research. Any time they need treatment, or surgery, select from the latest best research for that specific illness or injury. We have decades of superb mouse health optimization research, it should be applied.
- justinator 9mo agopaging Bryan Johnson
- overfeed 9mo agoCave Johnson too.
- directevolve 9mo agoThe Interventions Testing Program is the closest thing I know of along these lines. “ The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice. Investigators at any university, institute, company, or other organization are invited to recommend interventions for testing by submitting an application before the February deadline each year. Testing is carried out in the genetically heterogeneous UM-HET3 mouse stock at three sites — the Jackson Laboratory, the University of Michigan, and the University of Texas Health Science Center at San Antonio.” https://www.nia.nih.gov/research/dab/interventions-testing-program-itp https://www.nia.nih.gov/research/dab/interventions-testing-p...
- tantalor 9mo agoIs this a joke
- anonymous908213 9mo ago
- KnuthIsGod 9mo agoPioglitazone does this now. It is sometimes used for diabetes. https://pmc.ncbi.nlm.nih.gov/articles/PMC11862886/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11862886/
- radicaldreamer 9mo agoIs this available for dogs? I have an aging pup who has early arthritis and I'm considering NAD+ precursor supplements, but this seems much more promising.
- cebert 9mo agoI had microfracture knee surgery. My knee still doesn't feel 100%, and I would love to remain active and keep running. Today, I can do daily work activities, but some physical activities, like running, are painful. I hope this can become a viable solution for humans one day. It would remarkably improve my life.
- SilentM68 9mo agoOk, this sounds promising. Looking forward to when human trials start :)
- muragekibicho 9mo agoHuman testing should be legal. There'll be stuff like trafficking but that's already happening. Go direct or whatever Lulu said.
- hulitu 9mo agoFinally we can move the "enlarge your p*nis" emails from the Spam to the Inbox folder.