3 ms·
A weirdly low-information article. If anybody's curious, the drug is called AD109. It combines "an antimuscarinic, aroxybutynin (2.5 mg), with a selective nor
by A_D_E_P_T 10mo ago
A weirdly low-information article.
If anybody's curious, the drug is called AD109. It combines "an antimuscarinic, aroxybutynin (2.5 mg), with a selective norepinephrine reuptake inhibitor, atomoxetine (75 mg)." https://www.sciencedirect.com/science/article/pii/S2451865425001127 https://www.sciencedirect.com/science/article/pii/S245186542...
Atomoxetine is an old generic.
Aroxybutynin is (R)-Oxybutynin. Oxybutynin is an ancient (>50 year old) generic. Wikipedia notes that "the (R)-enantiomer is a more potent anticholinergic than either the racemate or the (S)-enantiomer, which is essentially without anticholinergic activity at doses used in clinical practice. However, (R)-oxybutynin administered alone offers little or no clinical benefit above and beyond the racemic mixture."
If you have sleep apnea and live in a country where you can buy most drugs OTC, this "Holy Grail" is something you can put together for yourself by tomorrow! Simply combine oxybutynin 5mg with atomoxetine 75mg, and done.
- PPoreddy 10mo agoThis is a huge value add to the above article, thanks for the breakdown. I'm gonna ask my doc to review this literature and evaluate whether it's worth being prescribed ahead of time for a off label trial of my own.