I've lately been using a combination of HTML5 Boilerplate and Chris Coyier's "don't overthink it" grid system to start a project. The result is just a basic pro

I've lately been using a combination of HTML5 Boilerplate and Chris Coyier's "don't overthink it" grid system to start a project. The result is just a basic prototype/wireframe. It's not too hard to skin and make nice. Adding modules later from Bootstrap and Foundation, as needed, is not hard to do. I much prefer that than starting with one large framework and hoping I'll have the inclination to refactor later. I'm normally not a fan of grid systems but Chris Coyier's grid system uses percents instead of pixels and is very lightweight. http://css-tricks.com/dont-overthink-it-grids/ http://css-tricks.com/dont-overthink-it-grids/