3 ms·
Understood. You may be interested to learn that Liraglutide, a GLP-1 Agonist, has been commercially available and commonly used since 2010 (15-years+) without a
by Someone1234 10mo ago
Understood. You may be interested to learn that Liraglutide, a GLP-1 Agonist, has been commercially available and commonly used since 2010 (15-years+) without any unknown/unexpected additional side-effects appearing. It was developed in 1998.
The main reason GLP-1 Agonists are suddenly more popular is two things:
- Liraglutide had to be taken daily, instead of weekly.
- Nobody every paid for Liraglutide to be clinically approved for weight-loss. It was an anti-diabetic medication; but the mechanism of action is the same.
Compared with liraglutide, semaglutide was engineered mainly with a longer, differently attached fatty-acid side chain that increases albumin binding and slows clearance, so it lasts longer; both drugs activate the GLP-1 receptor.