3 ms·

Indeed; there is a MASSIVE market demand for pills since few like needles and or the storage requirements of injectable Semaglutide. HOWEVER, this pill is ineff

Indeed; there is a MASSIVE market demand for pills since few like needles and or the storage requirements of injectable Semaglutide. HOWEVER, this pill is ineffective both in terms of medicine and cost, unfortunately. Several GLP-1 pills are in the pipeline, and there is near bottomless R&D budgets being spent on the area currently, but it isn't here yet and this isn't "it." I'd strongly suggest people ignore this release, and keep using injectable Semaglutide/Tirzepatide.

JumpCrisscross 10mo ago
> this pill is ineffective both in terms of medicine and cost Source?
- Someone1234 10mo ago
  Novo Nordisk's own clinical trials (OASIS 4, OASIS 1 Vs, STEP 1). In order for oral Semaglutide to be effective you need to substantially increase the oral dosages for the same effect. Meaning you need more Semaglutide for the same action-of-effect, which increases side effects (+2.6% Nausea, +6.9% Vomiting, based on 2.4mg Vs. 25mg). As I said above, this is being worked on (inc. by Novo Nordisk), but oral Semaglutide is a very naive early attempt. They got first to market, but that doesn't mean it makes sense for people who can handle injections; you cannot compare doses 1:1 because of how weak oral is, you need to compare action-of-effect. Once you look at effectiveness, oral costs more than injection.
  - JumpCrisscross 10mo ago
    > you need more Semaglutide for the same action-of-effect Sounds not ineffective. > oral costs more than injection Are these being marketed to the same populations?
cm2187 10mo ago
To me, anyone who tried injections quickly gets over the needle anxiety, it's pretty easy and painless. I don't think the market is people switching from injection to pills (particularly if less effective), to me the market is in people who are too anxious to start injections but would use a pill.
- tokai 10mo ago
  You underestimate how deep anxiety for needles can be. I have a friend that has gotten regular injections for years and it still happens that he faints from it.
  - JumpCrisscross 10mo ago
    > have a friend that has gotten regular injections for years and it still happens that he faints from it It could be an anxiety. I developed one after a nasty blood draw. When someone pointed out it was an anxiety response, it sort of just went away.
    - tokai 10mo ago
      Yeah its very much anxiety. He's a wreck when he has to get it done. He is fully aware but it doesn't matter, the physical response is too strong.
matthewmacleod 10mo ago
I mean… https://pubmed.ncbi.nlm.nih.gov/40934115/ https://pubmed.ncbi.nlm.nih.gov/40934115/ A total of 205 participants were randomly assigned to receive oral semaglutide, and 102 to receive placebo. The estimated mean change in body weight from baseline to week 64 was -13.6% in the oral semaglutide group and -2.2% in the placebo group (estimated difference, -11.4 percentage points; 95% confidence interval, -13.9 to -9.0; P<0.001). At what would be $10/day – why's that ineffective?
- Someone1234 10mo ago
  Because if you compare it to the injection trial, you'll see even higher weight loss, and even lower side effects. We're also producing 25mg of oral medication for the same effectiveness as 2.4mg of injection; that doesn't make economic sense.
  - JumpCrisscross 10mo ago
    > We're also producing 25mg of oral medication for the same effectiveness as 2.4mg of injection; that doesn't make economic sense Plenty of people can’t or won’t inject. And plenty of people don’t need 2.4mg injected. The pill is cheaper to make, distribute and take. That seems to make economic sense to me.

JumpCrisscross 10mo ago

> this pill is ineffective both in terms of medicine and cost Source?

Someone1234 10mo ago
Novo Nordisk's own clinical trials (OASIS 4, OASIS 1 Vs, STEP 1). In order for oral Semaglutide to be effective you need to substantially increase the oral dosages for the same effect. Meaning you need more Semaglutide for the same action-of-effect, which increases side effects (+2.6% Nausea, +6.9% Vomiting, based on 2.4mg Vs. 25mg). As I said above, this is being worked on (inc. by Novo Nordisk), but oral Semaglutide is a very naive early attempt. They got first to market, but that doesn't mean it makes sense for people who can handle injections; you cannot compare doses 1:1 because of how weak oral is, you need to compare action-of-effect. Once you look at effectiveness, oral costs more than injection.
- JumpCrisscross 10mo ago
  > you need more Semaglutide for the same action-of-effect Sounds not ineffective. > oral costs more than injection Are these being marketed to the same populations?

cm2187 10mo ago

To me, anyone who tried injections quickly gets over the needle anxiety, it's pretty easy and painless. I don't think the market is people switching from injection to pills (particularly if less effective), to me the market is in people who are too anxious to start injections but would use a pill.

tokai 10mo ago
You underestimate how deep anxiety for needles can be. I have a friend that has gotten regular injections for years and it still happens that he faints from it.
- JumpCrisscross 10mo ago
  > have a friend that has gotten regular injections for years and it still happens that he faints from it It could be an anxiety. I developed one after a nasty blood draw. When someone pointed out it was an anxiety response, it sort of just went away.
  - tokai 10mo ago
    Yeah its very much anxiety. He's a wreck when he has to get it done. He is fully aware but it doesn't matter, the physical response is too strong.

matthewmacleod 10mo ago

I mean… https://pubmed.ncbi.nlm.nih.gov/40934115/ https://pubmed.ncbi.nlm.nih.gov/40934115/ A total of 205 participants were randomly assigned to receive oral semaglutide, and 102 to receive placebo. The estimated mean change in body weight from baseline to week 64 was -13.6% in the oral semaglutide group and -2.2% in the placebo group (estimated difference, -11.4 percentage points; 95% confidence interval, -13.9 to -9.0; P<0.001). At what would be $10/day – why's that ineffective?

Someone1234 10mo ago
Because if you compare it to the injection trial, you'll see even higher weight loss, and even lower side effects. We're also producing 25mg of oral medication for the same effectiveness as 2.4mg of injection; that doesn't make economic sense.
- JumpCrisscross 10mo ago
  > We're also producing 25mg of oral medication for the same effectiveness as 2.4mg of injection; that doesn't make economic sense Plenty of people can’t or won’t inject. And plenty of people don’t need 2.4mg injected. The pill is cheaper to make, distribute and take. That seems to make economic sense to me.