3 ms·
This could mitigate side effects (stomach ulcers, bleeding) while retaining most of the benefits.
by walterbell 10mo ago
This could mitigate side effects (stomach ulcers, bleeding) while retaining most of the benefits.
- abrookewood 10mo agoSo in one case you get triple the daily dose (325 mg vs 81mg) every three days. I'm not sure how that would mitigate side effects?
- walterbell 10mo agoFrom the summary, only small difference between 81mg daily vs 81mg every 3 days, i.e 87% benefit at 33% averaged dosage. 325mg every third day: 86% inhibition 81mg per day: 85% inhibition 81mg every third day: 74% inhibition
- chr15m 10mo agoSome research suggests the stomach bleed risk comes from the platelet inhibition itself, which would mean you can't have the good effect without the bad.
- chr15m 10mo agoHang on, the 2015 study suggests otherwise. Daily dose suppressed PGE2 while 3-daily dose didn't. > Since PGE2 is involved in gastric healing, we understand that this new approach could be safer and as efficient as the standard daily therapy on a long-term basis.