4 ms·
Comparing benefits of every-third-day vs. daily low-dose aspirin therapy (2001)
- dzdt 10mo agoIs there a good heuristic now for which things on nih.gov.or cdc.gov are real science?
- illini1 10mo agoThis is a paper published from 2001 with no bearing on the current political climate.
- Dwedit 10mo agoThe concern is whether the file is unaltered from its original 2001 release.
- walterbell 10mo agoSource PDF with identical summary text: https://journals.sagepub.com/doi/epdf/10.1177/107602960100700111 https://journals.sagepub.com/doi/epdf/10.1177/10760296010070...
- walterbell 10mo agoThis could mitigate side effects (stomach ulcers, bleeding) while retaining most of the benefits.
- abrookewood 10mo agoSo in one case you get triple the daily dose (325 mg vs 81mg) every three days. I'm not sure how that would mitigate side effects?
- walterbell 10mo agoFrom the summary, only small difference between 81mg daily vs 81mg every 3 days, i.e 87% benefit at 33% averaged dosage. 325mg every third day: 86% inhibition 81mg per day: 85% inhibition 81mg every third day: 74% inhibition
- chr15m 10mo agoSome research suggests the stomach bleed risk comes from the platelet inhibition itself, which would mean you can't have the good effect without the bad.
- chr15m 10mo agoHang on, the 2015 study suggests otherwise. Daily dose suppressed PGE2 while 3-daily dose didn't. > Since PGE2 is involved in gastric healing, we understand that this new approach could be safer and as efficient as the standard daily therapy on a long-term basis.
- sathomasga 10mo agoFollow up in 2015 with essentially the same conclusions: "Acetylsalicylic Acid Daily vs Acetylsalicylic Acid Every 3 Days in Healthy Volunteers: Effect on Platelet Aggregation, Gastric Mucosa, and Prostaglandin E2 Synthesis" https://accp1.onlinelibrary.wiley.com/doi/abs/10.1002/jcph.685 https://accp1.onlinelibrary.wiley.com/doi/abs/10.1002/jcph.6...
- chr15m 10mo agoThanks for sharing this!
- polishdude20 10mo agoWhat's the benefit of taking aspirin regularly anyways?
- DougN7 10mo agoIt’s supposed to help reduce clotting, and thus help a bit to prevent a heart attack, at least that’s what I understood from my heart doctor. Generally you’d take the 81mg “baby aspirins” for this, not a full adult dose.
- Keyframe 10mo agoor in this case one fizzy tablet every three days? Are tehre people doing this long term? Doesn't sound all that compatible with colon.
- DougN7 10mo agoAfter a heart procedure my doctor told me to take the 81mg daily for the rest of my life. It’s been about 20 years now, with no side effects that I know of.
- OptionOfT 10mo agoI got prescribed 30 days of low-dose aspirin after my hip replacement to prevent clotting. 81mg. At least I didn't have side effects, the other anti-inflammatory made my brain foggy.
- hn_throw2025 10mo agoI would recommend asking your medical practitioner about enteric-coated forms. I am nearly nine months into NSAID gastritis from only a week of daily 75mg soluble Aspirin. I have had more painful acute illnesses in the past, but the grind of a long-term illness is new to me and it has been absolutely terrible.