4 ms·
More links - have a feeling they're going to get there with this kind of momentum. It provides an interesting possible alternative funding model to the patent
by ximeng 14y ago
More links - have a feeling they're going to get there with this kind of momentum.
It provides an interesting possible alternative funding model to the patent driven one. Would be better if there was some breakdown of the costs involved though, and a few more endorsements from scientists of the approach.
https://twitter.com/iCancerVirus https://twitter.com/iCancerVirus
http://www.guardian.co.uk/science/occams-corner/2012/oct/08/icancer-cancer-public-funding http://www.guardian.co.uk/science/occams-corner/2012/oct/08/...
http://www.indiegogo.com/icancervirus http://www.indiegogo.com/icancervirus <- the campaign page
http://www.netpatientfoundation.org/2012/10/icancer-campaign-launches-today-on-the-anniversary-of-steve-jobs-death/ http://www.netpatientfoundation.org/2012/10/icancer-campaign... <- with a link to a professor's view on this approach and others under development
http://www.telegraph.co.uk/health/9581988/The-cancer-killer-they-wont-pay-for.html http://www.telegraph.co.uk/health/9581988/The-cancer-killer-...
http://www.telegraph.co.uk/health/9544400/Would-I-takean-untested-cancer-treatment-myself-Hellyes.html http://www.telegraph.co.uk/health/9544400/Would-I-takean-unt...
http://mashable.com/2012/10/05/steve-jobs-philanthropy/ http://mashable.com/2012/10/05/steve-jobs-philanthropy/
Papers (from the Indiegogo page):
PAPER I
A novel chromogranin-A promoter-driven oncolytic adenovirus for midgut carcinoid therapy. <http://www.ncbi.nlm.nih.gov/pubmed/17438105> http://www.ncbi.nlm.nih.gov/pubmed/17438105>
Leja J, Dzojic H, Gustafson E, Oberg K, Giandomenico V, Essand M.
Clin Cancer Res. 2007 Apr 15;13(8):2455-62.
PAPER II
Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability. <http://www.ncbi.nlm.nih.gov/pubmed/20111709> http://www.ncbi.nlm.nih.gov/pubmed/20111709>
Leja J, Nilsson B, Yu D, Gustafson E, Akerström G, Oberg K, Giandomenico V, Essand M.
PAPER III
Adenovirus with hexon Tat-protein transduction domain modification exhibits increased therapeutic effect in experimental neuroblastoma and neuroendocrine tumors. <http://www.ncbi.nlm.nih.gov/pubmed/21957304> http://www.ncbi.nlm.nih.gov/pubmed/21957304>
Yu D, Jin C, Leja J, Majdalani N, Nilsson B, Eriksson F, Essand M.
J Virol. 2011 Dec;85(24):13114-23. Epub 2011 Sep 28.
PAPER IV
Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells. <http://www.ncbi.nlm.nih.gov/pubmed/21490682> http://www.ncbi.nlm.nih.gov/pubmed/21490682>
Leja J, Yu D, Nilsson B, Gedda L, Zieba A, Hakkarainen T, Åkerström G, Öberg K, Giandomenico V, Essand M.
Gene Ther. 2011 Nov;18(11):1052-62. doi: 10.1038/gt.2011.54. Epub 2011 Apr 14.
- delinquentme 14y agoAn interesting thing that you mention the funding model... Apparently this is a modified virus which already exists WITHIN humans. And as the telegraph article states, it seems the concept is just too simple to work. However the scientific community seems to feel differently.