3 ms·

from the linked drug trial article, https://www.nejm.org/doi/full/10.1056/NEJMoa2500969 https://www.nejm.org/doi/full/10.1056/NEJMoa2500969: Gastrointestinal

by canucker2016 10mo ago

from the linked drug trial article, https://www.nejm.org/doi/full/10.1056/NEJMoa2500969 https://www.nejm.org/doi/full/10.1056/NEJMoa2500969: Gastrointestinal adverse events were more common with oral semaglutide than with placebo (74.0% vs. 42.2%). That placebo value seems high (42.2%), given it's just a placebo (sugar pill?).

dpark 10mo ago
The placebo effect is shockingly strong. 30-50% report subjective benefits with placebo. Makes sense that about the same would report subjective side effects.
DANmode 10mo ago
As someone who almost died of (unrelated) gastroparesis: be absolutely sure you need this drug.