3 ms·
Regarding missing heritability: https://www.astralcodexten.com/p/the-good-news-is-that-one-side-has https://www.astralcodexten.com/p/the-good-news-is-that-one-s
by red75prime 11mo ago
Regarding missing heritability: https://www.astralcodexten.com/p/the-good-news-is-that-one-side-has https://www.astralcodexten.com/p/the-good-news-is-that-one-s...
"That is, once you include the rare variants, the amount of genetic variation that “should” exist but doesn’t shrinks to only 12%. Plausibly an even bigger study, investigating even rarer variants, could shrink the gap further, all the way to zero."
Of course, even then heritability will not be 100%.
- tptacek 10mo agoI don't think the rare-variant hypothesis is taken seriously anymore by practitioners, but feel free to cite.
- deleted 10mo ago[deleted]
- red75prime 10mo agoI think you might be mistaken, but feel free to cite metastudies that support you POV.
- tptacek 10mo agoFollow cites from here, and then look at the Twitter conversation between Gusev and Alexander Strudwick Young. https://theinfinitesimal.substack.com/p/the-missing-heritability-question https://theinfinitesimal.substack.com/p/the-missing-heritabi...
- red75prime 10mo agoThanks. I'll wait for proper meta-analysis.
- tptacek 10mo agoSo when you said "cite anything", you meant... Oh. Never mind. You rewrote your comment after I provided the cite. Well played.
- red75prime 10mo agoI clarified implied "anything [that supports your claim that it's not taken seriously anymore]". A proper way to do it is meta-analysis.
- tptacek 10mo agoWhy would you expect me to keep conversing after you stealthily reframed my comment to look like I had answered a different question? If you had anything real to say, you wouldn't have done that.