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> no increased risk of all-cause mortality > study including 22.7 million vaccinated individuals and 5.9 million unvaccinated individuals These are the import
by sa-code 10mo ago
> no increased risk of all-cause mortality
> study including 22.7 million vaccinated individuals and 5.9 million unvaccinated individuals
These are the important bits for the non medical folks
- lentil_soup 10mo agoAnd this bit: "vaccinated individuals had a 74% lower risk of death from severe COVID-19 and no increased risk of all-cause mortality"
- gwerbret 10mo ago> These are the important bits for the non medical folks Also significantly: "vaccinated individuals consistently had a lower risk of death, regardless of the cause."
- attila-lendvai 10mo agothat in itself could be healthy user bias (if a healthier subset was taking up the vaccine). did they control for that?
- biophysboy 10mo agoIts a cohort study, so you can only control for confounders. The 2nd paragraph of the discussion addresses the healthy-vaccinee effect you're referring to.
- blindriver 10mo agoThey define unvaccinated as anyone who wasn't vaccinated by Nov 2021. What if they got vaccinated afterwards?
- jmye 10mo agoWhat specific impact do you think that would have on this study? Do you think vaccines prior to Nov-2021 were safe and they were unsafe after? Do you think short term results, captured after Nov-2021 are more relevant than inclusive results prior?
- biophysboy 10mo agoThis is specified as an exclusion criteria in the Supplementary.
- blindriver 10mo agoNo they didn't. They excluded those that got the vaccine pre-May 2021 or those that got another vaccine besides Pfizer or Moderna.
- biophysboy 10mo agoThe target trial emulation specifies "individuals deceased or vaccinated during the 6 month grace period between the index date and the effective start of follow-up" as an exclusion criteria