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Also of interest is the observation that Ketamine (and PCP) are associated with NMDA Antagonist Neurotoxicity (Olney's Lesions), a form of brain damage. Not re

Also of interest is the observation that Ketamine (and PCP) are associated with NMDA Antagonist Neurotoxicity (Olney's Lesions), a form of brain damage. Not really something you should want to self medicate with at this point until more research is done. http://www.dextroverse.org/txt/olney.txt http://www.dextroverse.org/txt/olney.txt http://en.wikipedia.org/wiki/Olneys_lesions http://en.wikipedia.org/wiki/Olneys_lesions

civilian 14y ago
I originally majored in biochemistry, so this stuff is a nerdy enjoyment. The levels of ketamine required to form Olney's Lesions are 40mg/kg (given olney.txt), whereas the typical dose to reach a k-hole (the highest recreational level) is 1mg/kg. http://www.erowid.org/chemicals/ketamine/ketamine_dose.shtml http://www.erowid.org/chemicals/ketamine/ketamine_dose.shtml Also: http://en.wikipedia.org/wiki/Olneys_lesions#Controversy http://en.wikipedia.org/wiki/Olneys_lesions#Controversy In addition, the dosage levels of recreational ketamine are lower than the anesthetic dosages of ketamine. Repeated use of ketamine would probably still cause problems though, though the problems would be more along the lines of general drug dependency and not being able to think straight. > Not really something you should want to self medicate with at this point until more research is done. I dunno. Depression can be really dangerous & costly too-- both from suicide and just generally not being happy in life.
- dtf 14y ago
  Ketamine has been known to be "psychologically dependent" with heavy use - I guess the real world might seem a bit dull for some after all the crazy things that happen in the K-hole. But very heavy users can also experience extreme bladder damage, as their tolerance and dosage rise. It's fascinating to see these demonised recreational drugs being researched finally for their beneficial side-effects, sometimes in very small doses. Another one that comes to mind is the reported use of sub-psychoactive doses of LSD to combat the horror of cluster headaches.
  - civilian 14y ago
    My buddy suffers from cluster headaches and he self-retreated with low doses of LSD. But he was talking to his doctor in the last year, and he learned that there are ergotamine-based cluster headache medications. LSD also comes from that chemical, so he jumped on the opportunity. He's been cluster-headache free since January, and he's really happy that he doesn't have to rely on the black market for medication.
abailin 14y ago
Correct wikipedia link: http://en.wikipedia.org/wiki/Olney's_lesions edit: looks like the apostrophe is getting stripped

civilian 14y ago

I originally majored in biochemistry, so this stuff is a nerdy enjoyment. The levels of ketamine required to form Olney's Lesions are 40mg/kg (given olney.txt), whereas the typical dose to reach a k-hole (the highest recreational level) is 1mg/kg. http://www.erowid.org/chemicals/ketamine/ketamine_dose.shtml http://www.erowid.org/chemicals/ketamine/ketamine_dose.shtml Also: http://en.wikipedia.org/wiki/Olneys_lesions#Controversy http://en.wikipedia.org/wiki/Olneys_lesions#Controversy In addition, the dosage levels of recreational ketamine are lower than the anesthetic dosages of ketamine. Repeated use of ketamine would probably still cause problems though, though the problems would be more along the lines of general drug dependency and not being able to think straight. > Not really something you should want to self medicate with at this point until more research is done. I dunno. Depression can be really dangerous & costly too-- both from suicide and just generally not being happy in life.

dtf 14y ago
Ketamine has been known to be "psychologically dependent" with heavy use - I guess the real world might seem a bit dull for some after all the crazy things that happen in the K-hole. But very heavy users can also experience extreme bladder damage, as their tolerance and dosage rise. It's fascinating to see these demonised recreational drugs being researched finally for their beneficial side-effects, sometimes in very small doses. Another one that comes to mind is the reported use of sub-psychoactive doses of LSD to combat the horror of cluster headaches.
- civilian 14y ago
  My buddy suffers from cluster headaches and he self-retreated with low doses of LSD. But he was talking to his doctor in the last year, and he learned that there are ergotamine-based cluster headache medications. LSD also comes from that chemical, so he jumped on the opportunity. He's been cluster-headache free since January, and he's really happy that he doesn't have to rely on the black market for medication.

abailin 14y ago

Correct wikipedia link: http://en.wikipedia.org/wiki/Olney's_lesions edit: looks like the apostrophe is getting stripped