3 ms·

The Alzheimer """cure""" claim was already disproven by another study. Aside from that, the people who stop taking GLP, 75% gain 50-75% of their bodyweight back

by jorvi 11mo ago

The Alzheimer """cure""" claim was already disproven by another study. Aside from that, the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. No research out on, say, alcoholism yet, but I'd hazard a guess the results are the same. This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great but it saddles healthcare funding systems with an enormous burden for the next 20 years. Or you keep it private, which means you introduce an enormous gulf of health inequality. I hate that our solution to obesity is not the way Iceland treated it's youth drinking problem: reduce access to the harmful thing, give people money and support to do the healthy thing. Stick with it instead of cancelling the program if it doesn't show results in 4 years. Modern food (started in the 80s) has carefully been engineered to be as addictive as possible, health consequences be damned. Let's start fixing the problem there.

leoh 11mo ago
Effects on Alzheimer’s have not been disproven; it was shown that there wasn’t a perceivable benefit from oral semaglutide at the doses prescribed for folks with a certain degree of progression of the disease.
SubiculumCode 11mo ago
It should be treated like other important drugs. The U.S. buys the patent (or other variant) letting it become generic
philipkglass 11mo ago
This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great but it saddles healthcare funding systems with an enormous burden for the next 20 years. Semaglutide goes off-patent in 2032 in the US, and in 2026 in Canada and China: https://journals.library.columbia.edu/index.php/stlr/blog/view/653 https://journals.library.columbia.edu/index.php/stlr/blog/vi... https://www.ncbi.nlm.nih.gov/books/NBK602920/table/t03/ https://www.ncbi.nlm.nih.gov/books/NBK602920/table/t03/
- jorvi 11mo ago
  Wait, what? I thought these were extremely new drugs, only approved for a couple of years now.
  - apple4ever 11mo ago
    No they have been on the market for decades, but only recently have been found to be of use to non-diabetics. That's why you are hearing about them much more.
apple4ever 11mo ago
> the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. I don't think that framing is right, from another study: * 17.5% maintained 75+% of their weight loss * 25% maintained 50-75% of their weight loss * 23% maintained 25-50% of their weight loss * 24% maintained 0-25% of their weight loss At least 75% (possibly more!) maintained some form of weight loss 25% to 75%+. That is tremendous. And 43% maintained 50%+! For reducing being overweight, that is just amazing. > I hate that our solution to obesity is not the way Iceland treated it's youth drinking problem: reduce access to the harmful thing, give people money and support to do the healthy thing. Stick with it instead of cancelling the program if it doesn't show results in 4 years. I don't think it's possible to "reduce access to the harmful thing" when that thing is "food". Many people show long term results even stopping it. I don't understand this desire to say "people should suffer!" instead of taking something that helped them. Plenty of people have tried (me included) but if it was easy to lose weight, nobody would be long term overweight.
- rootusrootus 11mo ago
  > I don't understand this desire to say "people should suffer!" instead of taking something that helped them. Religion is my assumption. Or human nature more generically. Gluttony is one of the seven deadly sins in Christianity. So it is a moral issue for many people.
- maldev 11mo ago
  Exactly this. It gives you the CHOICE to stay healthy. Losing alot of weight is hard, before Ozempic I went to a weight loss clinic where they precribed stuff like the "hcg diet" or old medically assisted fads. I lost ALOT of weight, online they would all say the same stuff of "you'll just gain it back". A person cannot lose weight that fast normally, losing 70 or 100 pounds at 2-4 pounds a month is alot of time. But I was able to lose it and go from not being able to run, to being able to walk and run all day at festivals. Guess how it's easier to lose weight now... I think alot of people don't understand how hard it is to exercise or lose weight while fat, just due to the join pain and muscles. Let alone shoes not being meant to support you. Losing that, it becomes alot easier to "just go for a walk", or work on cardiovascular health. I got on it after I went on a trip with a friend and walking for a few hours had me bed ridden the next day and he was like "Ya, I'm tired but I could walk all day if I had to", and he wasn't fit. Now I'm that person and can fit in a whole meal with how much I burn from walking/running. I will say for the time I was on a GLP-1 at the end, it's amazing. It's almost the same effect as the other pills on appetite, but without the side effects. Phentermine and other stuff will make people manic, paranoid, or make your heart pop out of your chest. This type of drug is a godsend, and anyone who's committed will maintain the weight loss and live a healthier lifestyle.

by jorvi 11mo ago

leoh 11mo ago

Effects on Alzheimer’s have not been disproven; it was shown that there wasn’t a perceivable benefit from oral semaglutide at the doses prescribed for folks with a certain degree of progression of the disease.

SubiculumCode 11mo ago

It should be treated like other important drugs. The U.S. buys the patent (or other variant) letting it become generic

philipkglass 11mo ago

This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great but it saddles healthcare funding systems with an enormous burden for the next 20 years. Semaglutide goes off-patent in 2032 in the US, and in 2026 in Canada and China: https://journals.library.columbia.edu/index.php/stlr/blog/view/653 https://journals.library.columbia.edu/index.php/stlr/blog/vi... https://www.ncbi.nlm.nih.gov/books/NBK602920/table/t03/ https://www.ncbi.nlm.nih.gov/books/NBK602920/table/t03/

jorvi 11mo ago
Wait, what? I thought these were extremely new drugs, only approved for a couple of years now.
- apple4ever 11mo ago
  No they have been on the market for decades, but only recently have been found to be of use to non-diabetics. That's why you are hearing about them much more.

apple4ever 11mo ago

> the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. I don't think that framing is right, from another study: * 17.5% maintained 75+% of their weight loss * 25% maintained 50-75% of their weight loss * 23% maintained 25-50% of their weight loss * 24% maintained 0-25% of their weight loss At least 75% (possibly more!) maintained some form of weight loss 25% to 75%+. That is tremendous. And 43% maintained 50%+! For reducing being overweight, that is just amazing. > I hate that our solution to obesity is not the way Iceland treated it's youth drinking problem: reduce access to the harmful thing, give people money and support to do the healthy thing. Stick with it instead of cancelling the program if it doesn't show results in 4 years. I don't think it's possible to "reduce access to the harmful thing" when that thing is "food". Many people show long term results even stopping it. I don't understand this desire to say "people should suffer!" instead of taking something that helped them. Plenty of people have tried (me included) but if it was easy to lose weight, nobody would be long term overweight.

rootusrootus 11mo ago
> I don't understand this desire to say "people should suffer!" instead of taking something that helped them. Religion is my assumption. Or human nature more generically. Gluttony is one of the seven deadly sins in Christianity. So it is a moral issue for many people.
maldev 11mo ago
Exactly this. It gives you the CHOICE to stay healthy. Losing alot of weight is hard, before Ozempic I went to a weight loss clinic where they precribed stuff like the "hcg diet" or old medically assisted fads. I lost ALOT of weight, online they would all say the same stuff of "you'll just gain it back". A person cannot lose weight that fast normally, losing 70 or 100 pounds at 2-4 pounds a month is alot of time. But I was able to lose it and go from not being able to run, to being able to walk and run all day at festivals. Guess how it's easier to lose weight now... I think alot of people don't understand how hard it is to exercise or lose weight while fat, just due to the join pain and muscles. Let alone shoes not being meant to support you. Losing that, it becomes alot easier to "just go for a walk", or work on cardiovascular health. I got on it after I went on a trip with a friend and walking for a few hours had me bed ridden the next day and he was like "Ya, I'm tired but I could walk all day if I had to", and he wasn't fit. Now I'm that person and can fit in a whole meal with how much I burn from walking/running. I will say for the time I was on a GLP-1 at the end, it's amazing. It's almost the same effect as the other pills on appetite, but without the side effects. Phentermine and other stuff will make people manic, paranoid, or make your heart pop out of your chest. This type of drug is a godsend, and anyone who's committed will maintain the weight loss and live a healthier lifestyle.