3 ms·

Things get even fuzzier when you throw in heritable epigenetics too. We have a balance of these factors at least: - Genetics (DNA seq) - Epigentics (Histon

Things get even fuzzier when you throw in heritable epigenetics too. We have a balance of these factors at least: - Genetics (DNA seq) - Epigentics (Histone acetylation, base methylation etc) - Brain wiring from experiences - Chemical impact from experiences, e.g. nutrition, toxins, sunlight, muscle dev etc etc.

everdrive 11mo ago
> - Brain wiring from experiences > - Chemical impact from experiences, e.g. nutrition, toxins, sunlight, muscle dev etc etc. Are these not all part of the nurture / environment bucket? Or are we drawing a hard boundary between nurture (eg, parenting) and environment? (eg, lead in the pipes)
- the__alchemist 11mo ago
  I'm splitting up both "nature" and "nurture" into slightly less-broad categories. In the case of what you highlighted, yes. For example, epigentics is sort of both "nature" and "nurture", in that you can pick up these traits, and pass them on/get them passed on.
  - sudosysgen 11mo ago
    They can also simply get picked up in a correlated manner between twins due to the shared womb environment even if those correlated epigenetic traits are completely different from those of the parents.
- tptacek 11mo ago
  Genes interact with the environment. There aren't hard boundaries the way you've phrased them.
Aurornis 11mo ago
> Things get even fuzzier when you throw in heritable epigenetics too. Heritable epigenetics is a nascent field. We have yet to get any real promising research showing it even occurs to a significant degree in human. I would assume it's not a significant factor until we can find even some minimal evidence to suggest that it's an influence in humans. Even then, my guess is that the impact would be minimal. I know this is contrary to a lot of the "trauma passed down through epigenetics" narratives that are going around, but the actual science is in a very different place than the popular understanding of the topic.
- tptacek 11mo ago
  Whether or not epigenetic effects are passed down, epigenetics almost certainly impacts trait expression and complicates the "innate vs. environmental" narrative of hereditarians. I don't believe "inherited trauma" woo either, but epigenetics is much more fundamental to genetic science than that.
  - Aurornis 11mo ago
    Traditional epigenetics is very different than heritable epigenetics. Epigenetics is most definitely a factor in humans. Heritable epigenetics is a different story. There is some early evidence suggesting that transgenerational epigenetic effects appear in humans, but it's very early. Some of the first claimed discoveries of transgenerational epigenetic inheritance in humans turned out to be mistakes by researchers. A lot of the theories about human transgenerational epigenetic inheritance revolve around exposure to famines and food crises, which is unfortunately complicated by the way food crises shape dietary behaviors and eating habits which are also passed down via tradition (not genetically). The difficult part is that journalists often use "epigenetics" to refer to heritable epigenetics, and a lot of commenters make the same mistake.
    - tptacek 11mo ago
      Right, I'm not pushing back on you, just sticking up for the idea of paying attention to epigenetic factors in this broader question of innateness.
- sudosysgen 11mo ago
  These are twin studies, you don't need to get into heritable epigenitics. The expression of the shared environment in the womb would be reasonably expected to lead to epigenetic correlations in twins at a crucial stage of development where they would have the highest impact, without them being heritable. Put simply, the common epigenetics between twins need not be held in common with the parents.
  - Aurornis 11mo ago

everdrive 11mo ago

> - Brain wiring from experiences > - Chemical impact from experiences, e.g. nutrition, toxins, sunlight, muscle dev etc etc. Are these not all part of the nurture / environment bucket? Or are we drawing a hard boundary between nurture (eg, parenting) and environment? (eg, lead in the pipes)

the__alchemist 11mo ago
I'm splitting up both "nature" and "nurture" into slightly less-broad categories. In the case of what you highlighted, yes. For example, epigentics is sort of both "nature" and "nurture", in that you can pick up these traits, and pass them on/get them passed on.
- sudosysgen 11mo ago
  They can also simply get picked up in a correlated manner between twins due to the shared womb environment even if those correlated epigenetic traits are completely different from those of the parents.
tptacek 11mo ago
Genes interact with the environment. There aren't hard boundaries the way you've phrased them.

Aurornis 11mo ago

> Things get even fuzzier when you throw in heritable epigenetics too. Heritable epigenetics is a nascent field. We have yet to get any real promising research showing it even occurs to a significant degree in human. I would assume it's not a significant factor until we can find even some minimal evidence to suggest that it's an influence in humans. Even then, my guess is that the impact would be minimal. I know this is contrary to a lot of the "trauma passed down through epigenetics" narratives that are going around, but the actual science is in a very different place than the popular understanding of the topic.

tptacek 11mo ago
Whether or not epigenetic effects are passed down, epigenetics almost certainly impacts trait expression and complicates the "innate vs. environmental" narrative of hereditarians. I don't believe "inherited trauma" woo either, but epigenetics is much more fundamental to genetic science than that.
- Aurornis 11mo ago
  Traditional epigenetics is very different than heritable epigenetics. Epigenetics is most definitely a factor in humans. Heritable epigenetics is a different story. There is some early evidence suggesting that transgenerational epigenetic effects appear in humans, but it's very early. Some of the first claimed discoveries of transgenerational epigenetic inheritance in humans turned out to be mistakes by researchers. A lot of the theories about human transgenerational epigenetic inheritance revolve around exposure to famines and food crises, which is unfortunately complicated by the way food crises shape dietary behaviors and eating habits which are also passed down via tradition (not genetically). The difficult part is that journalists often use "epigenetics" to refer to heritable epigenetics, and a lot of commenters make the same mistake.
  - tptacek 11mo ago
    Right, I'm not pushing back on you, just sticking up for the idea of paying attention to epigenetic factors in this broader question of innateness.
sudosysgen 11mo ago
These are twin studies, you don't need to get into heritable epigenitics. The expression of the shared environment in the womb would be reasonably expected to lead to epigenetic correlations in twins at a crucial stage of development where they would have the highest impact, without them being heritable. Put simply, the common epigenetics between twins need not be held in common with the parents.
- Aurornis 11mo ago