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This is surprising. You'd expect cholesterol to accumulate in the blood vessels in the brain and create problems.

stefantalpalaru 11mo ago
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igor47 11mo ago
But dietary cholesterol is not linked to cholesterol in the blood vessels > We confirm from the review of the literature on epidemiological data, meta-analysis, and clinical interventions where dietary cholesterol challenges were utilized that there is not a direct correlation between cholesterol intake and blood cholesterol. https://pmc.ncbi.nlm.nih.gov/articles/PMC9143438/#abstract1 https://pmc.ncbi.nlm.nih.gov/articles/PMC9143438/#abstract1
- blargey 11mo ago
  Cheese is very high in saturated fats, which are linked to blood cholesterol (LDL). That said, Japanese cuisine is generally low in saturated fats, and adding 1+ instance of cheese per week is unlikely to tip it over doctor-un-recommended levels of sat. fat intake. Especially compared to the standard American diet.
braingravy 11mo ago
The blood vessels in the brain prevent cholesterol from passing through due to the blood-brain barrier. The first part of this abstract breaks down the current understanding nicely: https://www.mdpi.com/1467-3045/47/2/115 https://www.mdpi.com/1467-3045/47/2/115
- helterskelter 11mo ago
  TIL! Thank you.
- lofaszvanitt 11mo ago
  Then how come you start forgetting things when your cholesterol gets way high, like 4x the reference/normal value?
  - dchftcs 11mo ago
    Just speculating, but if your cardiovascular function degrades due to cholesterol, it should have an impact on the brain.
    - lofaszvanitt 11mo ago
      That's actually a good idea, thanks.
DiabloD3 11mo ago
Dietary cholesterol amount is not indicative of risk, unfortunately. I don't know why people keep repeating this. The body produces almost a gram of cholesterol a day, dietary cholesterol is around a quarter of that (depending on the person); if you try interfering with cholesterol production and somehow halt it, you will die. _Quality_ of dietary cholesterol is indicative of risk, but only a relatively small one, as the things that lead to damaged dietary lipoproteins also damages the endogenous ones as well (ie, ultra-processed foods, the chemicals in them try to ultra-process you too). Eating less cholesterol doesn't magically make your food good for you, and the average public shouldn't be continually told this.

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igor47 11mo ago

But dietary cholesterol is not linked to cholesterol in the blood vessels > We confirm from the review of the literature on epidemiological data, meta-analysis, and clinical interventions where dietary cholesterol challenges were utilized that there is not a direct correlation between cholesterol intake and blood cholesterol. https://pmc.ncbi.nlm.nih.gov/articles/PMC9143438/#abstract1 https://pmc.ncbi.nlm.nih.gov/articles/PMC9143438/#abstract1

blargey 11mo ago
Cheese is very high in saturated fats, which are linked to blood cholesterol (LDL). That said, Japanese cuisine is generally low in saturated fats, and adding 1+ instance of cheese per week is unlikely to tip it over doctor-un-recommended levels of sat. fat intake. Especially compared to the standard American diet.

braingravy 11mo ago

The blood vessels in the brain prevent cholesterol from passing through due to the blood-brain barrier. The first part of this abstract breaks down the current understanding nicely: https://www.mdpi.com/1467-3045/47/2/115 https://www.mdpi.com/1467-3045/47/2/115

helterskelter 11mo ago
TIL! Thank you.
lofaszvanitt 11mo ago
Then how come you start forgetting things when your cholesterol gets way high, like 4x the reference/normal value?
- dchftcs 11mo ago
  Just speculating, but if your cardiovascular function degrades due to cholesterol, it should have an impact on the brain.
  - lofaszvanitt 11mo ago
    That's actually a good idea, thanks.

DiabloD3 11mo ago

Dietary cholesterol amount is not indicative of risk, unfortunately. I don't know why people keep repeating this. The body produces almost a gram of cholesterol a day, dietary cholesterol is around a quarter of that (depending on the person); if you try interfering with cholesterol production and somehow halt it, you will die. _Quality_ of dietary cholesterol is indicative of risk, but only a relatively small one, as the things that lead to damaged dietary lipoproteins also damages the endogenous ones as well (ie, ultra-processed foods, the chemicals in them try to ultra-process you too). Eating less cholesterol doesn't magically make your food good for you, and the average public shouldn't be continually told this.