These only help if you can move the hot loop into some compiled code in those libraries. There's a lot of cases where this isn't possible and at that point ther

These only help if you can move the hot loop into some compiled code in those libraries. There's a lot of cases where this isn't possible and at that point there's just no way to make python fast (basically, as soon as you have a for loop in python that runs over every point in your dataset, you've lost).